dbPTM

VP26B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VP26B_MOUSE
UniProt AC	Q8C0E2
Protein Name	Vacuolar protein sorting-associated protein 26B
Gene Name	Vps26b
Organism	Mus musculus (Mouse).
Sequence Length	336
Subcellular Localization	Cytoplasm . Membrane Peripheral membrane protein . Early endosome . Late endosome . Endosomal localization is reported controversially. Does not localize to endosomes (PubMed:16190980). Localizes to early and late endosomal structures (PubMed:21920
Protein Description	Acts as component of the retromer cargo-selective complex (CSC). [PubMed: 21040701]
Protein Sequence	MSFFGFGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLSLKNPNKRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEVVLWRKGDIVRKSMSHQAAIASQRFEGTTSLGEVRTPGQLSDNNSRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Ubiquitination	GKVSLSLKNPNKRLE EEEEEEECCCCCCCE	67.97	22790023
253	Phosphorylation	IRLFLAGYELTPTMR EEEEECCEECCCCHH	11.36	25293948
256	Phosphorylation	FLAGYELTPTMRDIN EECCEECCCCHHHHH	12.55	25293948
258	Phosphorylation	AGYELTPTMRDINKK CCEECCCCHHHHHHH	21.43	25293948
286	Acetylation	EEERRYFKQQEVVLW HHHHHHHHHCCEEEE	41.98	22826441
301	Ubiquitination	RKGDIVRKSMSHQAA ECCHHHHHHHCHHHH	39.35	22790023
302	Phosphorylation	KGDIVRKSMSHQAAI CCHHHHHHHCHHHHH	18.23	25521595
304	Phosphorylation	DIVRKSMSHQAAIAS HHHHHHHCHHHHHHH	21.38	25521595
311	Phosphorylation	SHQAAIASQRFEGTT CHHHHHHHHCCCCCC	18.77	25521595
317	Phosphorylation	ASQRFEGTTSLGEVR HHHCCCCCCCCCCCC	13.15	22324799
318	Phosphorylation	SQRFEGTTSLGEVRT HHCCCCCCCCCCCCC	32.58	28833060
319	Phosphorylation	QRFEGTTSLGEVRTP HCCCCCCCCCCCCCC	33.93	26824392
325	Phosphorylation	TSLGEVRTPGQLSDN CCCCCCCCCCCCCCC	36.63	26824392
330	Phosphorylation	VRTPGQLSDNNSRQ- CCCCCCCCCCCCCC-	30.33	25521595
334	Phosphorylation	GQLSDNNSRQ----- CCCCCCCCCC-----	38.01	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VP26B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VP26B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VP26B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS29_MOUSE	Vps29	physical	18656452
VP26A_MOUSE	Vps26a	physical	18656452
VPS35_MOUSE	Vps35	physical	18656452

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VP26B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302 AND SER-304, ANDMASS SPECTROMETRY.	17242355 [Abstract]