dbPTM

UBP31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP31_HUMAN
UniProt AC	Q70CQ4
Protein Name	Ubiquitin carboxyl-terminal hydrolase 31
Gene Name	USP31
Organism	Homo sapiens (Human).
Sequence Length	1352
Subcellular Localization
Protein Description	May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)..
Protein Sequence	MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLNHLKFGLDYHRLSSPTQTAAKQGKMDSPTSRAGSDKIVLLVCNRACTGQQGKRFGLPFVLHLEKTIAWDLLQKEILEKMKYFLRPTVCIQVCPFSLRVVSVVGITYLLPQEEQPLCHPIVERALKSCGPGGTAHVKLVVEWDKETRDFLFVNTEDEYIPDAESVRLQRERHHQPQTCTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFRQEGDRRMKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAIPSWSANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSEDDGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMRPSWSLSAKLQMRSNSPSRFSGDSPIHSSASTLEKIGEAADDKVSISCFGSLRNLSSSYQEPSDSHSRREHKAVGRAPLAVMEGVFKDESDTRRLNSSVVDTQSKHSAQGDRLPPLSGPFDNNNQIAYVDQSDSVDSSPVKEVKAPSHPGSLAKKPESTTKRSPSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGRHSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRSPFPPGKSRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASLRSPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVCKNTGDDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQLDSGVPSSPGGRQSAEKSSKKLSSSMQTSARPSQKPQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSKVTAPGSGPP ---CCCCCCCCCCCC	30.76	19413330
22	Phosphorylation	ASGKEKRSFSKRLFR CCCCCCCCHHHHHHH	44.96	24719451
50	Phosphorylation	ASGPAAPSSPSSPSS CCCCCCCCCCCCCHH	50.59	25307156
51	Phosphorylation	SGPAAPSSPSSPSSA CCCCCCCCCCCCHHH	27.95	27732954
53	Phosphorylation	PAAPSSPSSPSSARS CCCCCCCCCCHHHHH	57.75	25850435
54	Phosphorylation	AAPSSPSSPSSARSV CCCCCCCCCHHHHHH	31.99	25850435
56	Phosphorylation	PSSPSSPSSARSVGS CCCCCCCHHHHHHHH	38.28	25850435
57	Phosphorylation	SSPSSPSSARSVGSF CCCCCCHHHHHHHHH	30.96	28857561
73	Phosphorylation	SRVLKTLSTLSHLSS HHHHHHHHHHHHHHC	32.31	30243723
74	Phosphorylation	RVLKTLSTLSHLSSE HHHHHHHHHHHHHCC	35.08	30243723
76	Phosphorylation	LKTLSTLSHLSSEGA HHHHHHHHHHHCCCC	23.59	30243723
79	Phosphorylation	LSTLSHLSSEGAAPD HHHHHHHHCCCCCCC	22.41	30243723
80	Phosphorylation	STLSHLSSEGAAPDR HHHHHHHCCCCCCCC	46.54	30243723
169	Phosphorylation	RAGRPEPSPDPEQPA CCCCCCCCCCCCCCC	40.03	30624053
202	Phosphorylation	RALWTLEYTPQHSRD HHHHHHCCCCCCCCC	27.17	-
247	Phosphorylation	VHEDLNHSVKQSGQP HHHHHHHHHHHCCCC	29.91	29978859
251	Phosphorylation	LNHSVKQSGQPPLKP HHHHHHHCCCCCCCC	33.41	29978859
343	Phosphorylation	IGVAVPLSGTVARLR EEEEEECCHHHHHHH	26.75	-
345	Phosphorylation	VAVPLSGTVARLREA EEEECCHHHHHHHHH	13.96	24260401
354	Phosphorylation	ARLREAVSMETKIPT HHHHHHHCCCCCCCC	20.25	23917254
398	Phosphorylation	DCIFAFETPEIFRPE CCEEEECCCCCCCCC	21.55	21815630
409	Phosphorylation	FRPEGILSQRGIHLN CCCCCHHHHCCEECC	18.86	24719451
428	Phosphorylation	HLKFGLDYHRLSSPT CHHHCCCHHHCCCHH	8.22	25106551
433	Phosphorylation	LDYHRLSSPTQTAAK CCHHHCCCHHHHHHH	36.24	25159151
440	Ubiquitination	SPTQTAAKQGKMDSP CHHHHHHHCCCCCCC	58.06	29967540
446	Phosphorylation	AKQGKMDSPTSRAGS HHCCCCCCCCCCCCC	26.95	28348404
453	Phosphorylation	SPTSRAGSDKIVLLV CCCCCCCCCCEEEEE	34.44	28348404
672	Phosphorylation	PLTGLDMTPHVVKRS CCCCCCCCHHHHHCC	15.20	24719451
684	Phosphorylation	KRSQSSWSLPSHWSP HCCCCCCCCCCCCCC	32.14	22617229
690	Phosphorylation	WSLPSHWSPWRRPYG CCCCCCCCCCCCCCC	14.79	22617229
696	Phosphorylation	WSPWRRPYGLGRDPE CCCCCCCCCCCCCHH	24.15	-
770	Phosphorylation	QRRTAIPSWSANSSV ECCCCCCCCCCCCCC	27.78	28985074
772	Phosphorylation	RTAIPSWSANSSVAG CCCCCCCCCCCCCCC	23.16	28985074
783	Phosphorylation	SVAGSTSSSLCEHWV CCCCCCCHHHHHHHH	27.67	28985074
791	Phosphorylation	SLCEHWVSRLPGSKP HHHHHHHHCCCCCCC	23.94	30576142
800	Phosphorylation	LPGSKPASVTSAASS CCCCCCCCHHHHHHC	34.16	30576142
802	Phosphorylation	GSKPASVTSAASSRR CCCCCCHHHHHHCCC	15.34	29255136
803	Phosphorylation	SKPASVTSAASSRRT CCCCCHHHHHHCCCC	21.49	29255136
806	Phosphorylation	ASVTSAASSRRTSLA CCHHHHHHCCCCCHH	24.88	29255136
807	Phosphorylation	SVTSAASSRRTSLAS CHHHHHHCCCCCHHH	22.51	29255136
810	Phosphorylation	SAASSRRTSLASLSE HHHHCCCCCHHHHHH	27.29	23401153
811	Phosphorylation	AASSRRTSLASLSES HHHCCCCCHHHHHHC	21.81	23401153
814	Phosphorylation	SRRTSLASLSESVEM CCCCCHHHHHHCEEC	37.41	28111955
847	Phosphorylation	SVQRQSLSSRSSVTS HHHCCCCCCCCCCCC	29.02	28985074
848	Phosphorylation	VQRQSLSSRSSVTSP HHCCCCCCCCCCCCC	41.28	28985074
877	Phosphorylation	SAKLQMRSNSPSRFS HHHHHHHCCCCCCCC	36.00	28450419
879	Phosphorylation	KLQMRSNSPSRFSGD HHHHHCCCCCCCCCC	26.04	28450419
881	Phosphorylation	QMRSNSPSRFSGDSP HHHCCCCCCCCCCCC	45.86	30576142
884	Phosphorylation	SNSPSRFSGDSPIHS CCCCCCCCCCCCCCC	40.35	28450419
887	Phosphorylation	PSRFSGDSPIHSSAS CCCCCCCCCCCCCCH	29.31	29255136
891	Phosphorylation	SGDSPIHSSASTLEK CCCCCCCCCCHHHHH	28.46	23312004
892	Phosphorylation	GDSPIHSSASTLEKI CCCCCCCCCHHHHHH	16.45	23927012
894	Phosphorylation	SPIHSSASTLEKIGE CCCCCCCHHHHHHHH	35.16	23312004
895	Phosphorylation	PIHSSASTLEKIGEA CCCCCCHHHHHHHHH	38.36	23312004
908	Phosphorylation	EAADDKVSISCFGSL HHCCCCEEEEHHHHH	17.96	28060719
910	Phosphorylation	ADDKVSISCFGSLRN CCCCEEEEHHHHHHC	8.90	24719451
914	Phosphorylation	VSISCFGSLRNLSSS EEEEHHHHHHCCCCC	12.14	28450419
919	Phosphorylation	FGSLRNLSSSYQEPS HHHHHCCCCCCCCCC	22.31	27642862
922	Phosphorylation	LRNLSSSYQEPSDSH HHCCCCCCCCCCCCC	20.88	27642862
991	Phosphorylation	DNNNQIAYVDQSDSV CCCCCEEEEECCCCC	13.24	27732954
995	Phosphorylation	QIAYVDQSDSVDSSP CEEEEECCCCCCCCC	27.65	27732954
997	Phosphorylation	AYVDQSDSVDSSPVK EEEECCCCCCCCCCC	32.83	27732954
1000	Phosphorylation	DQSDSVDSSPVKEVK ECCCCCCCCCCCCCC	34.09	27732954
1001	Phosphorylation	QSDSVDSSPVKEVKA CCCCCCCCCCCCCCC	29.28	27732954
1021	Phosphorylation	SLAKKPESTTKRSPS CCCCCCCCCCCCCCC	50.32	24719451
1022	Phosphorylation	LAKKPESTTKRSPSS CCCCCCCCCCCCCCC	34.37	22817900
1023	O-linked_Glycosylation	AKKPESTTKRSPSSK CCCCCCCCCCCCCCC	33.47	30379171
1023	Phosphorylation	AKKPESTTKRSPSSK CCCCCCCCCCCCCCC	33.47	22817900
1028	Phosphorylation	STTKRSPSSKGTSEP CCCCCCCCCCCCCCH	46.02	-
1029	Phosphorylation	TTKRSPSSKGTSEPE CCCCCCCCCCCCCHH	38.19	-
1032	Phosphorylation	RSPSSKGTSEPEKSL CCCCCCCCCCHHHHH	33.38	-
1052	Phosphorylation	ALASQESSLSSTSPS CCCCCCCCCCCCCCC	31.36	22817900
1054	Phosphorylation	ASQESSLSSTSPSSP CCCCCCCCCCCCCCC	33.25	23312004
1055	Phosphorylation	SQESSLSSTSPSSPL CCCCCCCCCCCCCCC	37.89	23312004
1056	Phosphorylation	QESSLSSTSPSSPLP CCCCCCCCCCCCCCC	41.08	22817900
1057	Phosphorylation	ESSLSSTSPSSPLPV CCCCCCCCCCCCCCE	25.40	25850435
1059	Phosphorylation	SLSSTSPSSPLPVKV CCCCCCCCCCCCEEE	44.34	22496350
1060	Phosphorylation	LSSTSPSSPLPVKVS CCCCCCCCCCCEEEE	33.56	23403867
1081	Phosphorylation	RSKADSSSRGSGRHS CCCCCCCCCCCCCCC	44.61	21130716
1088	Phosphorylation	SRGSGRHSSPAPAQP CCCCCCCCCCCCCCC	36.33	29396449
1089	Phosphorylation	RGSGRHSSPAPAQPK CCCCCCCCCCCCCCC	20.96	25849741
1099	Phosphorylation	PAQPKKESSPKSQDS CCCCCCCCCCCCCCC	61.90	28387310
1100	Phosphorylation	AQPKKESSPKSQDSV CCCCCCCCCCCCCCC	37.12	-
1103	Phosphorylation	KKESSPKSQDSVSSP CCCCCCCCCCCCCCC	42.47	-
1106	Phosphorylation	SSPKSQDSVSSPSPQ CCCCCCCCCCCCCHH	19.09	28387310
1108	Phosphorylation	PKSQDSVSSPSPQKQ CCCCCCCCCCCHHHH	40.25	26699800
1109	Phosphorylation	KSQDSVSSPSPQKQK CCCCCCCCCCHHHHH	27.52	20363803
1111	Phosphorylation	QDSVSSPSPQKQKSA CCCCCCCCHHHHHHC	41.74	20363803
1117	Phosphorylation	PSPQKQKSASALTYT CCHHHHHHCCCEEEE	25.59	24719451
1122	Phosphorylation	QKSASALTYTASSTS HHHCCCEEEEECCCC	20.67	21712546
1123	Phosphorylation	KSASALTYTASSTSA HHCCCEEEEECCCCC	10.93	22817900
1126	Phosphorylation	SALTYTASSTSAKKA CCEEEEECCCCCHHC	26.75	25159151
1129	Phosphorylation	TYTASSTSAKKASGP EEEECCCCCHHCCCC	39.79	28555341
1134	Phosphorylation	STSAKKASGPATRSP CCCCHHCCCCCCCCC	54.94	24719451
1140	Phosphorylation	ASGPATRSPFPPGKS CCCCCCCCCCCCCCC	26.91	32142685
1150	Phosphorylation	PPGKSRTSDHSLSRE CCCCCCCCCCCCCCC	32.01	28348404
1153	Phosphorylation	KSRTSDHSLSREGSR CCCCCCCCCCCCCCC	32.79	27794612
1169	Phosphorylation	SLGSDRASATSTSKP CCCCCCCCCCCCCCC	32.73	-
1171	Phosphorylation	GSDRASATSTSKPNS CCCCCCCCCCCCCCC	30.00	23403867
1172	Phosphorylation	SDRASATSTSKPNSP CCCCCCCCCCCCCCC	30.33	23403867
1173	Phosphorylation	DRASATSTSKPNSPR CCCCCCCCCCCCCCC	36.09	23403867
1174	Phosphorylation	RASATSTSKPNSPRV CCCCCCCCCCCCCCC	45.97	23403867
1178	Phosphorylation	TSTSKPNSPRVSQAR CCCCCCCCCCCCCCC	23.70	23403867
1198	Phosphorylation	GAGKHVRSSSMASLR CCCHHHCCCCCHHCC	26.19	27732954
1199	Phosphorylation	AGKHVRSSSMASLRS CCHHHCCCCCHHCCC	17.36	23403867
1200	Phosphorylation	GKHVRSSSMASLRSP CHHHCCCCCHHCCCC	21.44	23403867
1203	Phosphorylation	VRSSSMASLRSPSTS HCCCCCHHCCCCCHH	18.70	28270605
1206	O-linked_Glycosylation	SSMASLRSPSTSIKS CCCHHCCCCCHHHHH	28.61	30379171
1206	Phosphorylation	SSMASLRSPSTSIKS CCCHHCCCCCHHHHH	28.61	28270605
1208	Phosphorylation	MASLRSPSTSIKSGL CHHCCCCCHHHHHCC	35.71	23911959
1209	Phosphorylation	ASLRSPSTSIKSGLK HHCCCCCHHHHHCCC	37.54	28270605
1210	Phosphorylation	SLRSPSTSIKSGLKR HCCCCCHHHHHCCCC	32.15	22210691
1221	Phosphorylation	GLKRDSKSEDKGLSF CCCCCCCCHHHHHHH	55.79	20873877
1236	Acetylation	FKSALRQKETRRSTD HHHHHHHHHHHCCCC	55.40	19413330
1239	Methylation	ALRQKETRRSTDLGK HHHHHHHHCCCCHHH	31.48	115387295
1241	Phosphorylation	RQKETRRSTDLGKTA HHHHHHCCCCHHHHH	24.00	19413330
1261	Phosphorylation	AGGSSVKSVCKNTGD CCCCCHHHHHCCCCC	30.50	28060719
1266	Phosphorylation	VKSVCKNTGDDEAER HHHHHCCCCCCHHHH	27.73	28060719
1307	Phosphorylation	SAKHSLLSARKSKSS HHHHHHHHHHHCCCC	31.18	24719451
1311	Phosphorylation	SLLSARKSKSSQLDS HHHHHHHCCCCCCCC	32.01	30576142
1313	Phosphorylation	LSARKSKSSQLDSGV HHHHHCCCCCCCCCC	30.33	23911959
1314	Phosphorylation	SARKSKSSQLDSGVP HHHHCCCCCCCCCCC	38.20	24850871
1318	Phosphorylation	SKSSQLDSGVPSSPG CCCCCCCCCCCCCCC	50.73	30576142
1322	Phosphorylation	QLDSGVPSSPGGRQS CCCCCCCCCCCCHHH	46.92	25849741
1323	Phosphorylation	LDSGVPSSPGGRQSA CCCCCCCCCCCHHHH	22.84	25849741
1329	Phosphorylation	SSPGGRQSAEKSSKK CCCCCHHHHHHHHHH	36.71	30576142
1334	Phosphorylation	RQSAEKSSKKLSSSM HHHHHHHHHHHHHHH	44.89	18785766
1338	Phosphorylation	EKSSKKLSSSMQTSA HHHHHHHHHHHCCCC	29.28	29978859
1339	Phosphorylation	KSSKKLSSSMQTSAR HHHHHHHHHHCCCCC	40.02	29978859
1340	Phosphorylation	SSKKLSSSMQTSARP HHHHHHHHHCCCCCC	16.13	29978859
1343	Phosphorylation	KLSSSMQTSARPSQK HHHHHHCCCCCCCCC	18.73	29978859
1344	Phosphorylation	LSSSMQTSARPSQKP HHHHHCCCCCCCCCC	12.85	29978859
1348	Phosphorylation	MQTSARPSQKPQ--- HCCCCCCCCCCC---	45.33	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBP31_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP31_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP31_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TRAF2_HUMAN	TRAF2	physical	16214042
TF65_HUMAN	RELA	physical	16214042

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP31_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1052 AND THR-1056, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-428, AND MASSSPECTROMETRY.	19534553 [Abstract]