UBE4A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE4A_MOUSE
• UniProt AC: E9Q735
• Protein Name: Ubiquitin conjugation factor E4 A {ECO:0000305}
• Gene Name: Ube4a {ECO:0000312|MGI:MGI:2154580}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1028
• Subcellular Localization: Cytoplasm .
• Protein Description: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates..
• Protein Sequence: MTDQENNNNISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVSEISRSFRTHQEMCEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAIFARLLLQDPGNHLISMTSSTTLNLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALLLDEEVRTFPEVMIPVFDILLSRIKDLELCQILLYAYLDILLYFTRQKDMAKVFLEYIQPKDPSNGQMYQKTLLGVILNISCLLKTPGVVENHGFFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLSPETKHCILFWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFCKPRSSRLLTFNPTYCVLKDLNDEERKIKSVHMRGLDKETCLIPAVQEPTFPQSYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELSFPLPDGYSSLAYVPEFFADNLGDFLIFLRRFAEDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAEVLEAVMPHLDQTPSPLVSSVFHRKRVFCNFPYAPQLAEALIKVFVDIEFTGDPHQFEQKFNYRRPMYPILRYMWGTDCYRESIKYLSKIKIQQIEKDRGEWESLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLSFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPIMSTLMSDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	PFAALFGSLADAKQF HHHHHHHHHHHHHHH		30352176
386	Acetylation	EKIYQMLKNLLQLSP HHHHHHHHHHHHCCH		-
392	Phosphorylation	LKNLLQLSPETKHCI HHHHHHCCHHHHHHH		23737553
551	Phosphorylation	RDAQQSSSPAADNLR HHHHHCCCHHHHHHH		30635358
566	Phosphorylation	EQFERLMTIYLSTKT HHHHHHHHHHHCCCC		30635358
568	Phosphorylation	FERLMTIYLSTKTAM HHHHHHHHHCCCCCC		30635358
570	Phosphorylation	RLMTIYLSTKTAMTE HHHHHHHCCCCCCCC		30635358
571	Phosphorylation	LMTIYLSTKTAMTEP HHHHHHCCCCCCCCH		30635358
794	Ubiquitination	TPEARREKEAGLQMF CHHHHHHHHHHHHHH		-
900	Phosphorylation	TVPKDGRSYSPTLFA ECCCCCCCCCCCHHH		25293948
901	Phosphorylation	VPKDGRSYSPTLFAQ CCCCCCCCCCCHHHH		29472430
902	Phosphorylation	PKDGRSYSPTLFAQT CCCCCCCCCCHHHHH		30372032
904	Phosphorylation	DGRSYSPTLFAQTVR CCCCCCCCHHHHHHH		25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE4A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE4A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE4A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJC7_MOUSE	Dnajc7	physical	15189447
UBE4A_MOUSE	Ube4a	physical	11435423
UB2D3_HUMAN	UBE2D3	physical	11435423

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.