UAP1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UAP1L_HUMAN
• UniProt AC: Q3KQV9
• Protein Name: UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
• Gene Name: UAP1L1
• Organism: Homo sapiens (Human).
• Sequence Length: 507
• Protein Sequence: MASEQDVRARLQRAGQEHLLRFWAELAPEPRAALLAELALLEPEALREHCRRAAEACARPHGPPPDLAARLRPLPPERVGRASRSDPETRRRWEEEGFRQISLNKVAVLLLAGGQGTRLGVTYPKGMYRVGLPSRKTLYQLQAERIRRVEQLAGERHGTRCTVPWYVMTSEFTLGPTAEFFREHNFFHLDPANVVMFEQRLLPAVTFDGKVILERKDKVAMAPDGNGGLYCALEDHKILEDMERRGVEFVHVYCVDNILVRLADPVFIGFCVLQGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPETAQLRASDGSLLYNAGNICNHFFTRGFLKAVTREFEPLLKPHVAVKKVPYVDEEGNLVKPLKPNGIKMEKFVFDVFRFAKNFAALEVLREEEFSPLKNAEPADRDSPRTARQALLTQHYRWALRAGARFLDAHGAWLPELPSLPPNGDPPAICEISPLVSYSGEGLEVYLQGREFQSPLILDEDQAREPQLQES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	QGTRLGVTYPKGMYR CCCEEEEEECCCCEE	32.10	26074081
123	Phosphorylation	GTRLGVTYPKGMYRV CCEEEEEECCCCEEC	10.67	26074081
125	Ubiquitination	RLGVTYPKGMYRVGL EEEEEECCCCEECCC	45.99	-
128	Phosphorylation	VTYPKGMYRVGLPSR EEECCCCEECCCCCC	15.71	-
175	Ubiquitination	MTSEFTLGPTAEFFR EECEEEECCHHHHHH	17.91	27667366
281	Ubiquitination	QGADCGAKVVEKAYP CCCCCCCEEHHCCCC	31.90	-
285	Ubiquitination	CGAKVVEKAYPEEPV CCCEEHHCCCCCCCC	41.43	29967540
342	Ubiquitination	FFTRGFLKAVTREFE HHHHHHHHHHHHHCH	38.25	27667366
353	Ubiquitination	REFEPLLKPHVAVKK HHCHHHCCCCEEEEE	40.54	29967540
372	Ubiquitination	DEEGNLVKPLKPNGI CCCCCEECCCCCCCC	48.04	29967540
407	Phosphorylation	VLREEEFSPLKNAEP HHCHHHCCCCCCCCC	32.38	28450419
419	Phosphorylation	AEPADRDSPRTARQA CCCCCCCCHHHHHHH	19.71	28674151
469	O-linked_Glycosylation	PPAICEISPLVSYSG CCCEEEEECCEEECC	7.01	29351928
473	O-linked_Glycosylation	CEISPLVSYSGEGLE EEEECCEEECCCCEE	22.67	29351928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UAP1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UAP1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UAP1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KFA_HUMAN	AFMID	physical	26344197
PHS_HUMAN	PCBD1	physical	26344197
RB11B_HUMAN	RAB11B	physical	26344197
SDHB_HUMAN	SDHB	physical	26344197
WDR1_HUMAN	WDR1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.