| UniProt ID | TYRP1_HUMAN | |
|---|---|---|
| UniProt AC | P17643 | |
| Protein Name | 5,6-dihydroxyindole-2-carboxylic acid oxidase | |
| Gene Name | TYRP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 537 | |
| Subcellular Localization |
Melanosome membrane Single-pass type I membrane protein . Melanosome . Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanos |
|
| Protein Description | Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions. [PubMed: 28661582 May regulate or influence the type of melanin synthesized] | |
| Protein Sequence | MSAPKLLSLGCIFFPLLLFQQARAQFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVALIFGTASYLIRARRSMDEANQPLLTDQYQCYAEEYEKLQNPNQSVV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | GMCCPDLSPVSGPGT CCCCCCCCCCCCCCC | 30.54 | - | |
| 96 | N-linked_Glycosylation | VWPLRFFNRTCHCNG EEEEEECCCEEECCC | 35.32 | 28661582 | |
| 104 | N-linked_Glycosylation | RTCHCNGNFSGHNCG CEEECCCCCCCCCCC | 17.58 | 28661582 | |
| 137 | Phosphorylation | RRNLLDLSKEEKNHF ECHHHCCCHHHHHHH | 37.37 | - | |
| 181 | N-linked_Glycosylation | GNTPQFENISIYNYF CCCCCCCCEEEEEEE | 34.30 | 28661582 | |
| 207 | Phosphorylation | FLGVGQESFGEVDFS EECCCCCCCEECCCC | 30.57 | - | |
| 222 | Phosphorylation | HEGPAFLTWHRYHLL CCCCCEEEHHHHHHH | 16.87 | - | |
| 270 | Phosphorylation | DDLMGSRSNFDSTLI HHCCCCCCCCCCCCC | 43.47 | - | |
| 304 | N-linked_Glycosylation | DTLGTLCNSTEDGPI CCHHHHCCCCCCCCC | 55.89 | 28661582 | |
| 344 | Phosphorylation | LEVGLFDTPPFYSNS HHHCCCCCCCCCCCC | 26.06 | 22210691 | |
| 350 | N-linked_Glycosylation | DTPPFYSNSTNSFRN CCCCCCCCCCCCCCC | 41.28 | 28661582 | |
| 385 | N-linked_Glycosylation | NLAHLFLNGTGGQTH HHHHHHHCCCCCCCC | 38.35 | 28661582 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TYRP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TYRP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TYRP1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GIPC1_HUMAN | GIPC1 | physical | 11441007 | |
| RB11A_HUMAN | RAB11A | physical | 16354686 | |
| TRFE_HUMAN | TF | physical | 16354686 | |
| RAB5A_HUMAN | RAB5A | physical | 16354686 | |
| HSP74_HUMAN | HSPA4 | physical | 16354686 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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