TTHL_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTHL_ARATH
• UniProt AC: Q9LVM5
• Protein Name: Uric acid degradation bifunctional protein TTL
• Gene Name: TTL
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 324
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Peroxisome .
• Protein Description: Involved in the last two steps of the degradation of uric acid, i.e. the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) and its stereoselective decarboxylation to (S)-allantoin. Might function as a negative regulator to modulate brassinosteroid-mediated plant growth..
• Protein Sequence: MAMEIGEDEWKVCCGSSEFAKQMSTSGPLTSQEAIYTARDIWFNQVNVTDWLEAFSAHPQIGNTPSPSINSDFARRSVSEQSTAFATTSASALQELAEWNVLYKKKFGFIFIICASGRTHAEMLHALKERYENRPIVELEIAAMEQMKITELRMAKLFSDKAKVISETDSSSSPVSTKPQDRLRIIGGHLNVAAEAKAPKRSRPPITTHVLDVSRGAPAAGVEVHLEVWSGTTGPSFVHGGGGVWSSVGTSATDRDGRSGPLMDLVDALNPGTYRISFDTAKYSPGCFFPYVSIVFQVTESQKWEHFHVPLLLAPFSFSTYRGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMEIGEDE ------CCCCCCCCC	12.33	22223895
166	Phosphorylation	SDKAKVISETDSSSS CCCCEEEECCCCCCC	37.11	23776212
168	Phosphorylation	KAKVISETDSSSSPV CCEEEECCCCCCCCC	34.10	23776212
170	Phosphorylation	KVISETDSSSSPVST EEEECCCCCCCCCCC	39.27	23776212
170 (in isoform 2)	Phosphorylation	-	39.27	23776212
171	Phosphorylation	VISETDSSSSPVSTK EEECCCCCCCCCCCC	37.33	23776212
171 (in isoform 2)	Phosphorylation	-	37.33	23776212
171 (in isoform 3)	Phosphorylation	-	37.33	19880383
172	Phosphorylation	ISETDSSSSPVSTKP EECCCCCCCCCCCCC	42.48	23776212
172 (in isoform 2)	Phosphorylation	-	42.48	23776212
173	Phosphorylation	SETDSSSSPVSTKPQ ECCCCCCCCCCCCCH	31.13	23776212
173 (in isoform 2)	Phosphorylation	-	31.13	23776212
176	Phosphorylation	DSSSSPVSTKPQDRL CCCCCCCCCCCHHCE	33.81	23776212
176 (in isoform 2)	Phosphorylation	-	33.81	23776212
177	Phosphorylation	SSSSPVSTKPQDRLR CCCCCCCCCCHHCEE	47.15	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTHL_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTHL_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTHL_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTHL_ARATH	TTL	physical	21798944
SUMO3_ARATH	SUMO3	physical	20855607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-173, ANDMASS SPECTROMETRY.
PubMed: 19376835