TRPV1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPV1_MOUSE
• UniProt AC: Q704Y3
• Protein Name: Transient receptor potential cation channel subfamily V member 1
• Gene Name: Trpv1
• Organism: Mus musculus (Mouse).
• Sequence Length: 839
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendritic spine membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mostly, but not exclusively expressed in postsy
• Protein Description: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. [PubMed: 15194687]
• Protein Sequence: MEKWASLDSDESEPPAQENSCPDPPDRDPNSKPPPAKPHIFATRSRTRLFGKGDSEEASPMDCPYEEGGLASCPIITVSSVVTLQRSVDGPTCLRQTSQDSVSTGVETPPRLYDRRSIFDAVAQSNCQELESLLSFLQKSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDIARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTNMYNEILILGAKLHPTLKLEELTNKKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTTAAYYRPVEGLPPYKLNNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPVESPPHKCRGSACRPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDFRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHSTQPEEVQLKHYTGSLKPEDAEVFKDSMAPGEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	PRLYDRRSIFDAVAQ CCCCCHHHHHHHHHH	28.62	-
145	Phosphorylation	QKSKKRLTDSEFKDP HHHHHCCCCCCCCCC	41.32	16954222
266	Acetylation	TNQLAIVKFLLQNSW HCHHHHHHHHHHCCC	24.96	7610815
330	Phosphorylation	TLKLEELTNKKGLTP CCCHHHHCCCCCCCH	48.55	-
371	Phosphorylation	RHLSRKFTEWAYGPV HHHHHHHHHHHHCCC	33.38	16954222
407	Phosphorylation	IAYSSSETPNRHDML EEEECCCCCCCCHHE	28.01	-
503	Phosphorylation	YFLQRRPSLKSLFVD HHHHHCCCCHHHCCC	46.77	-
605	N-linked_Glycosylation	TLIEDGKNNSLPVES HHHHCCCCCCCCCCC	49.18	-
628	Phosphorylation	ACRPGNSYNSLYSTC CCCCCCCHHHHHHHH	16.87	25521595
630	Phosphorylation	RPGNSYNSLYSTCLE CCCCCHHHHHHHHHH	22.05	25521595
634	Phosphorylation	SYNSLYSTCLELFKF CHHHHHHHHHHHHHH	13.93	25521595
705	Phosphorylation	WKLQRAITILDTEKS HHHHHHHHHHHCHHH	17.95	-
775	Phosphorylation	EGVKRTLSFSLRSGR CCCCEEEEEEECCCC	16.51	22942356
777	Phosphorylation	VKRTLSFSLRSGRVS CCEEEEEEECCCCCC	21.35	22942356
801	Phosphorylation	VPLLRDASTRDRHST HHHHCCCCCCCCCCC	28.41	18495351
821	Phosphorylation	QLKHYTGSLKPEDAE HHHHCCCCCCHHHCH	25.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
117	S	Phosphorylation	Kinase	PKA	-	Uniprot
117	S	Phosphorylation	Kinase	PKD	-	Uniprot
145	T	Phosphorylation	Kinase	PKA	-	Uniprot
371	T	Phosphorylation	Kinase	PKA	-	Uniprot
407	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
503	S	Phosphorylation	Kinase	PRKCE	P16054	Uniprot
801	S	Phosphorylation	Kinase	PRKCE	P16054	Uniprot
801	S	Phosphorylation	Kinase	PRKCZ	Q02956	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
117	S	Phosphorylation	Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites probably including Ser-117 as a major phosphorylation site.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPV1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFIP3_HUMAN	RAB11FIP3	physical	15883036
AKAP5_MOUSE	Akap5	physical	18463244
KAPCA_MOUSE	Prkaca	physical	18463244

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.