TRI66_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI66_MOUSE
• UniProt AC: Q924W6
• Protein Name: Tripartite motif-containing protein 66
• Gene Name: Trim66
• Organism: Mus musculus (Mouse).
• Sequence Length: 1242
• Subcellular Localization: Nucleus . Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.
• Protein Description: May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association..
• Protein Sequence: MARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHVPAPGGPLFARAQKGSSGVNGGSGDFALYCPLHTQEVLKLFCETCDVLTCHSCLMVEHKEHRCRHVEEVLQNQRMLLESVTSQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKSSVPFLFSKELIVFQMQRLLETRCNTDPGSPWSIRFTWEPNFWTKQLASLGCITTEGGQLTRADAAAASYGSLQGQPSFYQSHQAPMAQQEALSHPSHKFQSPALCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPSEMVPHQLGSLQCSTLLPREKELACSPHPPKLMQPWLEPQPPAEQESTSQRPGPQLVSQPVCIVPPQDVQPGAHAQPTIQTPSIQVQLGHHQKLKLSHFQQQPQQQPPPPPPPPPPPQHAPPPLPPSQHLASSQHESPPGPACSQNVDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQVTEEPPAPEGPKPALPVDKNTAAPLPQTSGEETPHSVPPVDGTSQHSSPNVVRKHATSVSIMGFSNTVEMELSSTRLARTIEPQIHRVSSLTAAPTHTIPSLLSGPPQTVSSLMSVSNHAMPSLTASHLQPVPNLVRGTFQSTSNLRGDSSQAITGLASNHSQAGPSLMSGHTQAAPSLATCPLQGMPPVSDVHVEPRSVSSPGSGPAAESLGTRDGAESSLGNALCKMESEDCTRFSDSVGQGPTASSLDGPKDLAIPSELEEPINLSVKKPFLAPVINTSTALQQYRNPKEYENFEQGALELDTKENSDIRAISSEPKIPYVRLERLKICAASSGEMPVFKLKPQKNSQDGNFLLVIECGTESSSMSIKVSQNSLPDASQGPGLGGRKVTVTSLTGQQPQEVESTSEEHRLIPRAPGAKKNTPAPIENEDFCAVCINGGELLCCDRCPKVYHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENARYGHPGVRVLPGLSMYDQKKCEKLVLSLCCNSLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPDKCFAQPQQEDSDSEDVSGESGCSTPQGFPWPPYMQEGIQPKRRRRHMENEKTKRVSFRLANSISQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Acetylation	VTSQVAHKKSSLQTS HHHHHHHHHHHHHHH	44.61	6584793
242	Phosphorylation	RCNTDPGSPWSIRFT HCCCCCCCCCEEEEE	28.69	28066266
245	Phosphorylation	TDPGSPWSIRFTWEP CCCCCCCEEEEEECC	13.79	28066266
533	Phosphorylation	LQLSQTKSPQHLQQT CCCCCCCCHHHHHHH	32.93	29899451
764	Phosphorylation	DVHVEPRSVSSPGSG EEEEECCCCCCCCCC	36.75	29899451
766	Phosphorylation	HVEPRSVSSPGSGPA EEECCCCCCCCCCHH	31.87	28066266
767	Phosphorylation	VEPRSVSSPGSGPAA EECCCCCCCCCCHHH	30.99	28066266
770	Phosphorylation	RSVSSPGSGPAAESL CCCCCCCCCHHHHHC	45.01	28066266
803	Phosphorylation	SEDCTRFSDSVGQGP CCCCCCCCCCCCCCC	26.19	25521595
805	Phosphorylation	DCTRFSDSVGQGPTA CCCCCCCCCCCCCCC	27.27	25521595
881	Phosphorylation	NSDIRAISSEPKIPY CCCCEECCCCCCCCE	27.88	29899451
938	Phosphorylation	SSMSIKVSQNSLPDA CCEEEEEECCCCCCC	20.74	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI66_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI66_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI66_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBX5_MOUSE	Cbx5	physical	15322135
CBX1_MOUSE	Cbx1	physical	15322135
TRI66_MOUSE	Trim66	physical	15322135

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.