TNR11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR11_MOUSE
• UniProt AC: O35305
• Protein Name: Tumor necrosis factor receptor superfamily member 11A
• Gene Name: Tnfrsf11a
• Organism: Mus musculus (Mouse).
• Sequence Length: 625
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein .
• Protein Description: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells..
• Protein Sequence: MAPRARRRRQLPAPLLALCVLLVPLQVTLQVTPPCTQERHYEHLGRCCSRCEPGKYLSSKCTPTSDSVCLPCGPDEYLDTWNEEDKCLLHKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNSDCECCRRNTECAPGFGAQHPLQLNKDTVCTPCLLGFFSDVFSSTDKCKPWTNCTLLGKLEAHQGTTESDVVCSSSMTLRRPPKEAQAYLPSLIVLLLFISVVVVAAIIFGVYYRKGGKALTANLWNWVNDACSSLSGNKESSGDRCAGSHSATSSQQEVCEGILLMTREEKMVPEDGAGVCGPVCAAGGPWAEVRDSRTFTLVSEVETQGDLSRKIPTEDEYTDRPSQPSTGSLLLIQQGSKSIPPFQEPLEVGENDSLSQCFTGTESTVDSEGCDFTEPPSRTDSMPVSPEKHLTKEIEGDSCLPWVVSSNSTDGYTGSGNTPGEDHEPFPGSLKCGPLPQCAYSMGFPSEAAASMAEAGVRPQDRADERGASGSGSSPSDQPPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGPGSAEPESEPVGRPVQEETLAHRDSFAGTAPRFPDVCATGAGLQEQGAPRQKDGTSRPVQEQGGAQTSLHTQGSGQCAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	PCTQERHYEHLGRCC CCCCHHHHHHHHHHH	15.97	28576409
106	N-linked_Glycosylation	LVAVDPGNHTAPRRC EEEECCCCCCCCCCE	34.42	23039992
175	N-linked_Glycosylation	DKCKPWTNCTLLGKL CCCCCCCCCCCEEEE	16.95	-
198	Phosphorylation	SDVVCSSSMTLRRPP HHEEECCCCEECCCC	10.25	-
571	Phosphorylation	ETLAHRDSFAGTAPR HHHHCCCCCCCCCCC	19.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR11_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUH_MOUSE	Rbpj	genetic	22249448
P85A_MOUSE	Pik3r1	physical	11406619
CBL_MOUSE	Cbl	physical	11406619
TRAF6_MOUSE	Traf6	physical	11406619
TRAF6_MOUSE	Traf6	physical	14500659

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.