TNFC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNFC_HUMAN
• UniProt AC: Q06643
• Protein Name: Lymphotoxin-beta
• Gene Name: LTB
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional..
• Protein Sequence: MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
158	Phosphorylation	DPQGRSVTLRSSLYR CCCCCEEEHHHHHHH	20.08	24719451
222	N-linked_Glycosylation	RGERVYVNISHPDMV CCCEEEEECCCHHHC	16.62	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNFC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNFC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNFC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNFB_HUMAN	LTA	physical	7995952
TNR1A_HUMAN	TNFRSF1A	physical	7995952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.