TLC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLC1_ARATH
• UniProt AC: Q39002
• Protein Name: ADP,ATP carrier protein 1, chloroplastic
• Gene Name: AATP1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 624
• Subcellular Localization: Plastid, chloroplast membrane ; Multi-pass membrane protein .
• Protein Description: May function as an ATP importer..
• Protein Sequence: MEAVIQTRGLLSLPTKPIGVRSQLQPSHGLKQRLFAAKPRNLHGLSLSFNGHKKFQTFEPTLHGISISHKERSTEFICKAEAAAAGDGAVFGEGDSAAVVASPKIFGVEVATLKKIIPLGLMFFCILFNYTILRDTKDVLVVTAKGSSAEIIPFLKTWVNLPMAIGFMLLYTKLSNVLSKKALFYTVIVPFIIYFGAFGFVMYPLSNYIHPEALADKLLTTLGPRFMGPIAILRIWSFCLFYVMAELWGSVVVSVLFWGFANQITTVDEAKKFYPLFGLGANVALIFSGRTVKYFSNLRKNLGPGVDGWAVSLKAMMSIVVGMGLAICLLYWWVNRYVPLPTRSKNKKEKPKMGTMESLKFLVSSPYIRDLATLVVAYGISINLVEVTWKSKLKAQFPSPNEYSAFMGDFSTCTGVATFTMMLLSQYVFNKYGWGVAAKITPTVLLLTGVAFFSLILFGGPFAPLVAKLGMTPLLAAVYVGALQNIFSKSAKYSLFDPCKEMAYIPLDEDTKVKGKAAIDVVCNPLGKSGGALIQQFMILSFGSLANSTPYLGMILLVIVTAWLAAAKSLEGQFNSLRSEEELEKEMERASSVKIPVVSQDESGNGSLGESPSSSPEKSAPTNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Acetylation	STEFICKAEAAAAGD CCCEEHHHHHHHCCC	13.78	22223895
342	Phosphorylation	NRYVPLPTRSKNKKE HHCCCCCCCCCCCCC	56.08	24894044
344	Phosphorylation	YVPLPTRSKNKKEKP CCCCCCCCCCCCCCC	42.96	24894044
591	Phosphorylation	EKEMERASSVKIPVV HHHHHHHHCCCCEEE	41.72	19376835
592	Phosphorylation	KEMERASSVKIPVVS HHHHHHHCCCCEEEE	26.84	19376835
599	Phosphorylation	SVKIPVVSQDESGNG CCCCEEEECCCCCCC	31.95	19376835
603	Phosphorylation	PVVSQDESGNGSLGE EEEECCCCCCCCCCC	45.94	19376835
607	Phosphorylation	QDESGNGSLGESPSS CCCCCCCCCCCCCCC	36.88	19376835
611	Phosphorylation	GNGSLGESPSSSPEK CCCCCCCCCCCCCCC	28.43	19376835
613	Phosphorylation	GSLGESPSSSPEKSA CCCCCCCCCCCCCCC	53.37	19376835
614	Phosphorylation	SLGESPSSSPEKSAP CCCCCCCCCCCCCCC	53.98	19376835
615	Phosphorylation	LGESPSSSPEKSAPT CCCCCCCCCCCCCCC	41.22	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLC1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLC1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HHP2_ARATH	HHP2	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
UBC32_ARATH	UBC32	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
BET12_ARATH	ATBET12	physical	24833385
TBL18_ARATH	TBL18	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592, AND MASSSPECTROMETRY.
PubMed: 19376835