TIC40_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIC40_ARATH
• UniProt AC: Q9FMD5
• Protein Name: Protein TIC 40, chloroplastic
• Gene Name: TIC40
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 447
• Subcellular Localization: Plastid, chloroplast inner membrane ; Single-pass membrane protein .
• Protein Description: Involved in protein precursor import into chloroplasts. Part of the motor complex consisting of a co-chaperone (TIC40) and a chaperone (HSP93) associated with the import channel (TIC110). Causes the release of bound transit peptides from TIC110 and stimulates ATP hydrolysis by HSP93. Involved in reinsertion of proteins from the chloroplast stroma into the inner membrane..
• Protein Sequence: MENLTLVSCSASSPKLLIGCNFTSSLKNPTGFSRRTPNIVLRCSKISASAQSQSPSSRPENTGEIVVVKQRSKAFASIFSSSRDQQTTSVASPSVPVPPPSSSTIGSPLFWIGVGVGLSALFSYVTSNLKKYAMQTAMKTMMNQMNTQNSQFNNSGFPSGSPFPFPFPPQTSPASSPFQSQSQSSGATVDVTATKVETPPSTKPKPTPAKDIEVDKPSVVLEASKEKKEEKNYAFEDISPEETTKESPFSNYAEVSETNSPKETRLFEDVLQNGAGPANGATASEVFQSLGGGKGGPGLSVEALEKMMEDPTVQKMVYPYLPEEMRNPETFKWMLKNPQYRQQLQDMLNNMSGSGEWDKRMTDTLKNFDLNSPEVKQQFNQIGLTPEEVISKIMENPDVAMAFQNPRVQAALMECSENPMNIMKYQNDKEVMDVFNKISQLFPGMTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	Phosphorylation	EKKEEKNYAFEDISP HHHHHCCCCCCCCCH	24.60	23820729
243	Phosphorylation	EDISPEETTKESPFS CCCCHHHCCCCCCCC	41.32	23820729
445	Sulfoxidation	ISQLFPGMTG----- HHHHCCCCCC-----	3.85	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIC40_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIC40_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIC40_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLPC1_ARATH	CLPC1	genetic	15659100
TI110_ARATH	TIC110	physical	23382192
OEP80_ARATH	OEP80	physical	23382192
TI110_ARATH	TIC110	physical	17158958
OEP80_ARATH	OEP80	physical	12805212
TI110_ARATH	TIC110	physical	12805212
CLPC2_ARATH	HSP93-III	physical	12805212

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.