TI110_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TI110_ARATH
• UniProt AC: Q8LPR9
• Protein Name: Protein TIC110, chloroplastic
• Gene Name: TIC110
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1016
• Subcellular Localization: Plastid, chloroplast inner membrane ; Multi-pass membrane protein .
• Protein Description: Involved in protein precursor import into chloroplasts. Forms a voltage-dependent cation-selective channel at the inner envelope of chloroplasts, which specifically responds to a transit peptide. Associates with both the precursor and mature forms of the preprotein..
• Protein Sequence: MNPSLVTAINAPISPSPRSPLLSHFLPTLPHRFSKSECLSRRRYRVSFPRSSAASSDQLSVSTQAKNPGIHGNKKELTGLQPIVEKMTPPVRLATSAVVLAASLATGYGLGLRLAGSRNIAFGGAAVAGAAGGAVVYALNSAVPEVAAISLHNYVAEFEDPASVTKDDVEKIADRYGVNKGDEAFQAEICDIYCRYVTSVLPTEGQSLKGDEVAKIVKFKNALGIDEPDAAAMHMEIGRRIFRQRLETGEREGDAEQRRAFMRLVYVSALVFGDASSFLLPWKRVLKVTDAQVEIAIRENAKQLYAERLKLVGRDINVENLVDLRKSQLSFKLSDELAEDLFREHTRKVVVENISSALSILKSRTRAAKSLASVVEELEKVLEFNNLLVSLKSHSEADQFARGVGPISLIGDESDFERRMDDLKLLYRAYVTDALSGGRLEENKLVAMSQLRNILGLGKREAEAISVDVTSKSYRKRLANAVSSGDLEAQDSKAKYLQKLCEELHFDAQKAGAIHEEIYRQKLQQCVTDGELSDDNVAALLRLRVMLCIPQQTVDTAHAEICGTIFEKVVRDAISSGVDGYDAETRKSVRKAAHGLRLSRETAMSIASKAVRRVFTNYIRRARAAENRTDSAKELKKMIAFNTLVVTEMVADIKGESSDKAPEEDPVQEKEEDDEDEEWGSLESLRKTRPDKELAEKMGKPGQTEITLKDDLPDRDRIDLYKTYLLYCVTGEVTRIPFGAQITTKRDDSEYLLLNQLGGILGLSSKEIVNIHVGLAEQAFRQQAEVILADGQLTKARVEQLDELQKQVGLPQPQAEKVIKNITTTKMANAIETAVNQGRLNIKQIRELKEANVSLDSMIAVSLREKLFKKTVSDIFSSGTGEFDETEVYQTIPSDLSIDVEKAKRVVHDLAQSRLSNSLVQAVALLRQRNSKGVVLSLNDLLACDKAVPAEPMSWEVSEELSDLYAIYSKSDPKPAPEKVLRLQYLLGIDDSTATALREMEDGALSSAAEEGNFVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Acetylation	RVSFPRSSAASSDQL EEECCCCCCCCCCCC	29.18	22223895
52	O-linked_Glycosylation	RVSFPRSSAASSDQL EEECCCCCCCCCCCC	29.18	-
196	Phosphorylation	ICDIYCRYVTSVLPT HHHHHHHHHHHCCCC	12.43	23111157
373	Phosphorylation	RAAKSLASVVEELEK HHHHHHHHHHHHHHH	31.80	30291188
483	Phosphorylation	KRLANAVSSGDLEAQ HHHHHHHHCCCHHHH	26.62	30291188
484	Phosphorylation	RLANAVSSGDLEAQD HHHHHHHCCCHHHHH	29.72	19376835
492	Phosphorylation	GDLEAQDSKAKYLQK CCHHHHHHHHHHHHH	23.56	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TI110_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TI110_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TI110_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIC40_ARATH	TIC40	physical	15829604
TIC32_ARATH	AT4G23430	physical	15180984
TIC40_ARATH	TIC40	physical	15180984
TI22L_ARATH	AT3G23710	physical	15180984
OEP80_ARATH	OEP80	physical	16582010
TIC40_ARATH	TIC40	physical	17535810

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.