CLPC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLPC1_ARATH
• UniProt AC: Q9FI56
• Protein Name: Chaperone protein ClpC1, chloroplastic {ECO:0000303|PubMed:11299370}
• Gene Name: CLPC1 {ECO:0000303|PubMed:11299370}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 929
• Subcellular Localization: Plastid, chloroplast stroma . Plastid, chloroplast membrane . The membrane association is important for the in vivo functions.
• Protein Description: Molecular chaperone that hydrolyzes ATP and is associated with the chloroplast protein import apparatus. May function as the motor for chloroplast protein translocation, as translocation requires ATP hydrolysis in the stroma. May interact with a ClpP-like protease involved in degradation of denatured proteins in the chloroplast. Involved in the regulation of chlorophyll b biosynthesis through the destabilization of chlorophyllide a oxygenase (CAO) protein in response to the accumulation of chlorophyll b. Involved in leaf iron homeostasis..
• Protein Sequence: MAMATRVLAQSTPPSLACYQRNVPSRGSGRSRRSVKMMCSQLQVSGLRMQGFMGLRGNNALDTLGKSRQDFHSKVRQAMNVPKGKASRFTVKAMFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGIAAKVLKSMGINLKDARVEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGSEHLLLGLLREGEGVAARVLENLGADPSNIRTQVIRMVGENNEVTANVGGGSSSNKMPTLEEYGTNLTKLAEEGKLDPVVGRQPQIERVVQILGRRTKNNPCLIGEPGVGKTAIAEGLAQRIASGDVPETIEGKKVITLDMGLLVAGTKYRGEFEERLKKLMEEIRQSDEIILFIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTLDEYRKHIEKDPALERRFQPVKVPEPTVDETIQILKGLRERYEIHHKLRYTDESLVAAAQLSYQYISDRFLPDKAIDLIDEAGSRVRLRHAQVPEEARELEKELRQITKEKNEAVRGQDFEKAGTLRDREIELRAEVSAIQAKGKEMSKAESETGEEGPMVTESDIQHIVSSWTGIPVEKVSTDESDRLLKMEETLHKRIIGQDEAVKAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKSELAKALAAYYFGSEEAMIRLDMSEFMERHTVSKLIGSPPGYVGYTEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMMLQILEDGRLTDSKGRTVDFKNTLLIMTSNVGSSVIEKGGRRIGFDLDYDEKDSSYNRIKSLVTEELKQYFRPEFLNRLDEMIVFRQLTKLEVKEIADILLKEVFERLKKKEIELQVTERFKERVVDEGYNPSYGARPLRRAIMRLLEDSMAEKMLAREIKEGDSVIVDVDAEGNVTVLNGGSGTPTTSLEEQEDSLPVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	NVPKGKASRFTVKAM CCCCCCCCHHHHHHH	31.26	28011693
90	Phosphorylation	KGKASRFTVKAMFER CCCCCHHHHHHHHHH	21.71	28011693
164	Phosphorylation	EKIIGRGSGFVAVEI EEHHCCCCCEEEEEC	27.91	30291188
174	Phosphorylation	VAVEIPFTPRAKRVL EEEECCCCHHHHHHH	13.40	30291188
225	Phosphorylation	ENLGADPSNIRTQVI HHCCCCHHHHHHHHH	45.49	30291188
327	Phosphorylation	ASGDVPETIEGKKVI HCCCCCCCCCCEEEE	20.47	29654922
602	Sulfoxidation	ESDRLLKMEETLHKR HHHHHHHHHHHHHHH	5.92	25693801
884	Sulfoxidation	EDSMAEKMLAREIKE HHHHHHHHHHHHHHC	2.39	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLPC1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLPC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLPC1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CLPC1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.