TF2H1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2H1_MOUSE
• UniProt AC: Q9DBA9
• Protein Name: General transcription factor IIH subunit 1
• Gene Name: Gtf2h1
• Organism: Mus musculus (Mouse).
• Sequence Length: 547
• Subcellular Localization: Nucleus.
• Protein Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription..
• Protein Sequence: MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSTSSHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTSLEDKPLDEGYSISSVPSTSNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSVDGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAVNQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQSRRLMKKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
239	Acetylation	DRLNTGSKDLFAECA HHCCCCCHHHHHHHH	60.85	23806337
262	Acetylation	TMVSLGVKNPMLDLT HHHHCCCCCCCCCCC	54.24	7923711
293	Phosphorylation	PSTSNSKSIKENSNA CCCCCCCCHHHCCCC	38.42	28059163
298	Phosphorylation	SKSIKENSNAAIIKR CCCHHHCCCCCHHHH	29.01	28059163
338	Phosphorylation	PSSVDGNSGDTDCFQ CCCCCCCCCCCCCCH	43.50	-
356	Phosphorylation	KRAKLQESIEYEDLG HHHHHHHHCCEECCC	14.04	-
359	Phosphorylation	KLQESIEYEDLGNNN HHHHHCCEECCCCCC	17.05	25159016
414	Phosphorylation	RQEMEAYTPKLTQVL HHHHHHHCHHHHHHH	22.46	29899451
515	Phosphorylation	QEKIRRQYLSTNLVS HHHHHHHHHHHHHHH	10.78	26643407
517	Phosphorylation	KIRRQYLSTNLVSHI HHHHHHHHHHHHHHH	15.43	26643407
518	Phosphorylation	IRRQYLSTNLVSHIE HHHHHHHHHHHHHHH	29.94	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2H1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2H1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2H1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFE2_MOUSE	Nfe2	physical	20211142
TLX3_MOUSE	Tlx3	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.