TCAM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCAM2_MOUSE
• UniProt AC: Q8BJQ4
• Protein Name: TIR domain-containing adapter molecule 2
• Gene Name: Ticam2
• Organism: Mus musculus (Mouse).
• Sequence Length: 232
• Subcellular Localization: Cytoplasm. Golgi apparatus. Cell membrane . Early endosome . Late endosome. Endoplasmic reticulum. Localized to the plasma membrane as a result of myristoylation..
• Protein Description: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response..
• Protein Sequence: MGVGKSKLDKCPLSWHKKDSVDADQDGHESDSKNSEEACLRGFVEQSSGSEPPTGEQDQPEAKGAGPEEQDEEEFLKFVILHAEDDTDEALRVQDLLQNDFGIRPGIVFAEMPCGRLHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVSRQHKYNSVIPMRPLNSPLPRERTPLALQTINALEEESQGFSTQVERIFRESVFERQQSIWKETRSVSQKQFIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGVGKSKLD ------CCCCCCCCC	36.56	-
20	Phosphorylation	LSWHKKDSVDADQDG CCCCCCCCCCCCCCC	30.67	30387612
30	Phosphorylation	ADQDGHESDSKNSEE CCCCCCCCCCCCHHH	41.32	30635358
32	Phosphorylation	QDGHESDSKNSEEAC CCCCCCCCCCHHHHH	42.91	30635358
35	Phosphorylation	HESDSKNSEEACLRG CCCCCCCHHHHHHHH	40.32	30635358
47	Phosphorylation	LRGFVEQSSGSEPPT HHHHHHHCCCCCCCC	24.14	30635358
48	Phosphorylation	RGFVEQSSGSEPPTG HHHHHHCCCCCCCCC	46.14	30635358
50	Phosphorylation	FVEQSSGSEPPTGEQ HHHHCCCCCCCCCCC	49.21	30635358
54	Phosphorylation	SSGSEPPTGEQDQPE CCCCCCCCCCCCCCC	65.16	30635358
151	Phosphorylation	TWCNFQFYTSLMNSV CCHHHHHHHHHHHHH	5.66	-
164	Phosphorylation	SVSRQHKYNSVIPMR HHHHHHCCCCCCCCC	15.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCAM2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCAM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCAM2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_MOUSE	Traf6	physical	25828701
M3K7_MOUSE	Map3k7	physical	25828701
TCAM2_MOUSE	Ticam2	physical	25828701

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.