TC132_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TC132_ARATH
• UniProt AC: Q9SLF3
• Protein Name: Translocase of chloroplast 132, chloroplastic
• Gene Name: TOC132
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1206
• Subcellular Localization: Plastid, chloroplast outer membrane; Single-pass membrane protein. Cytoplasm. Cycles between the cytoplasm and chloroplast, probably as a soluble preprotein receptor. The anchoring to the chloroplast outer membrane required the GTPase activity and GD
• Protein Description: GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast..
• Protein Sequence: MGDGTEFVVRSDREDKKLAEDRISDEQVVKNELVRSDEVRDDNEDEVFEEAIGSENDEQEEEEDPKRELFESDDLPLVETLKSSMVEHEVEDFEEAVGDLDETSSNEGGVKDFTAVGESHGAGEAEFDVLATKMNGDKGEGGGGGSYDKVESSLDVVDTTENATSTNTNGSNLAAEHVGIENGKTHSFLGNGIASPKNKEVVAEVIPKDDGIEEPWNDGIEVDNWEERVDGIQTEQEVEEGEGTTENQFEKRTEEEVVEGEGTSKNLFEKQTEQDVVEGEGTSKDLFENGSVCMDSESEAERNGETGAAYTSNIVTNASGDNEVSSAVTSSPLEESSSGEKGETEGDSTCLKPEQHLASSPHSYPESTEVHSNSGSPGVTSREHKPVQSANGGHDVQSPQPNKELEKQQSSRVHVDPEITENSHVETEPEVVSSVSPTESRSNPAALPPARPAGLGRASPLLEPASRAPQQSRVNGNGSHNQFQQAEDSTTTEADEHDETREKLQLIRVKFLRLAHRLGQTPHNVVVAQVLYRLGLAEQLRGRNGSRVGAFSFDRASAMAEQLEAAGQDPLDFSCTIMVLGKSGVGKSATINSIFDEVKFCTDAFQMGTKRVQDVEGLVQGIKVRVIDTPGLLPSWSDQAKNEKILNSVKAFIKKNPPDIVLYLDRLDMQSRDSGDMPLLRTISDVFGPSIWFNAIVGLTHAASVPPDGPNGTASSYDMFVTQRSHVIQQAIRQAAGDMRLMNPVSLVENHSACRTNRAGQRVLPNGQVWKPHLLLLSFASKILAEANALLKLQDNIPGRPFAARSKAPPLPFLLSSLLQSRPQPKLPEQQYGDEEDEDDLEESSDSDEESEYDQLPPFKSLTKAQMATLSKSQKKQYLDEMEYREKLLMKKQMKEERKRRKMFKKFAAEIKDLPDGYSENVEEESGGPASVPVPMPDLSLPASFDSDNPTHRYRYLDSSNQWLVRPVLETHGWDHDIGYEGVNAERLFVVKEKIPISVSGQVTKDKKDANVQLEMASSVKHGEGKSTSLGFDMQTVGKELAYTLRSETRFNNFRRNKAAAGLSVTHLGDSVSAGLKVEDKFIASKWFRIVMSGGAMTSRGDFAYGGTLEAQLRDKDYPLGRFLTTLGLSVMDWHGDLAIGGNIQSQVPIGRSSNLIARANLNNRGAGQVSVRVNSSEQLQLAMVAIVPLFKKLLSYYYPQTQYGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDGTEFVV ------CCCCCEEEE	54.05	22223895
54	Phosphorylation	VFEEAIGSENDEQEE HHHHHHCCCCCHHHC	27.41	23776212
72	Phosphorylation	PKRELFESDDLPLVE HHHHHHHCCCCCHHH	29.14	30291188
103	Phosphorylation	AVGDLDETSSNEGGV HHCCCCCCCCCCCCC	36.80	23776212
104	Phosphorylation	VGDLDETSSNEGGVK HCCCCCCCCCCCCCC	29.17	23776212
105	Phosphorylation	GDLDETSSNEGGVKD CCCCCCCCCCCCCCE	46.44	23776212
195	Phosphorylation	FLGNGIASPKNKEVV CCCCCCCCCCCCCEE	34.19	30291188
296	Phosphorylation	NGSVCMDSESEAERN CCCEEECCHHHHHHH	19.01	19880383
298	Phosphorylation	SVCMDSESEAERNGE CEEECCHHHHHHHCC	46.16	19880383
337	Phosphorylation	SSPLEESSSGEKGET CCCCCCCCCCCCCCC	45.72	-
363	Phosphorylation	HLASSPHSYPESTEV HHCCCCCCCCCCCCC	45.85	-
374	Phosphorylation	STEVHSNSGSPGVTS CCCCCCCCCCCCCCC	43.60	29654922
376	Phosphorylation	EVHSNSGSPGVTSRE CCCCCCCCCCCCCCC	20.50	29654922
398	Phosphorylation	NGGHDVQSPQPNKEL CCCCCCCCCCCCHHH	25.92	-
436	Phosphorylation	PEVVSSVSPTESRSN CEEEECCCCCCCCCC	28.22	23111157
459	Phosphorylation	PAGLGRASPLLEPAS CCCCCCCCCCCCCCC	18.08	29654922
552	Phosphorylation	GSRVGAFSFDRASAM CCCCCCEECHHHHHH	26.21	25561503
844	Phosphorylation	DEDDLEESSDSDEES CCCCCCCCCCCCCHH	30.03	26187819
845	Phosphorylation	EDDLEESSDSDEESE CCCCCCCCCCCCHHH	44.40	26187819
847	Phosphorylation	DLEESSDSDEESEYD CCCCCCCCCCHHHHH	49.20	26187819
851	Phosphorylation	SSDSDEESEYDQLPP CCCCCCHHHHHCCCC	39.13	26187819
853	Phosphorylation	DSDEESEYDQLPPFK CCCCHHHHHCCCCHH	20.47	19880383
1036	Phosphorylation	SLGFDMQTVGKELAY CCCCCHHHCCHHHHH	25.29	24894044
1043	Phosphorylation	TVGKELAYTLRSETR HCCHHHHHHHHCCHH	20.94	24894044
1044	Phosphorylation	VGKELAYTLRSETRF CCHHHHHHHHCCHHC	15.30	24894044
1047	Phosphorylation	ELAYTLRSETRFNNF HHHHHHHCCHHCCHH	46.57	24894044
1049	Phosphorylation	AYTLRSETRFNNFRR HHHHHCCHHCCHHHC	41.63	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TC132_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TC132_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TC132_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TI110_ARATH	TIC110	physical	15829604
TC120_ARATH	TOC120	physical	15829604

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.