TC120_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TC120_ARATH
• UniProt AC: Q9LUS2
• Protein Name: Translocase of chloroplast 120, chloroplastic
• Gene Name: TOC120
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1089
• Subcellular Localization: Plastid, chloroplast outer membrane; Single-pass membrane protein. Cytoplasm. Cycles between the cytoplasm and chloroplast, probably as a soluble preprotein receptor. The anchoring to the chloroplast outer membrane required the GTPase activity and GD
• Protein Description: GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast..
• Protein Sequence: MGDGAEIVTRLYGDEKKLAEDGRISELVGSDEVKDNEEEVFEEAIGSQEGLKPESLKTDVLQEDFPLASNDEVCDLEETSRNERGVENLKVNYSEIGESHGEVNEQCITTKEADSDLVTLKMNDYDHGEVADADISYGKMASSLDVVENSEKATSNLATEDVNLENGNTHSSSENGVVSPDENKELVAEVISVSACSVETGSNGIDDEKWEEEIDVSAGMVTEQRNGKTGAEFNSVKIVSGDKSLNDSIEVAAGTLSPLEKSSSEEKGETESQNSNGGHDIQSNKEIVKQQDSSVNIGPEIKESQHMERESEVLSSVSPTESRSDTAALPPARPAGLGRAAPLLEPAPRVTQQPRVNGNVSHNQPQQAEDSTTAETDEHDETREKLQFIRVKFLRLSHRLGQTPHNVVVAQVLYRLGLAEQLRGRNGSRVGAFSFDRASAMAEQLEAAAQDPLDFSCTIMVLGKSGVGKSATINSIFDELKISTDAFQVGTKKVQDIEGFVQGIKVRVIDTPGLLPSWSDQHKNEKILKSVRAFIKKSPPDIVLYLDRLDMQSRDSGDMPLLRTITDVFGPSIWFNAIVGLTHAASAPPDGPNGTASSYDMFVTQRSHVIQQAIRQAAGDMRLMNPVSLVENHSACRTNRAGQRVLPNGQVWKPHLLLLSFASKILAEANALLKLQDNIPGGQFATRSKAPPLPLLLSSLLQSRPQAKLPEQQYDDEDDEDDLDESSDSEEESEYDELPPFKRLTKAEMTKLSKSQKKEYLDEMEYREKLFMKRQMKEERKRRKLLKKFAAEIKDMPNGYSENVEEERSEPASVPVPMPDLSLPASFDSDNPTHRYRYLDTSNQWLVRPVLETHGWDHDIGYEGVNAERLFVVKDKIPVSFSGQVTKDKKDAHVQLELASSVKHGEGRSTSLGFDMQNAGKELAYTIRSETRFNKFRKNKAAAGLSVTLLGDSVSAGLKVEDKLIANKRFRMVMSGGAMTSRGDVAYGGTLEAQFRDKDYPLGRFLSTLGLSVMDWHGDLAIGGNIQSQVPIGRSSNLIARANLNNRGAGQVSIRVNSSEQLQLAVVALVPLFKKLLTYYSPEQMQYGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDGAEIVT ------CCCHHHHHH	54.05	-
9	Phosphorylation	GDGAEIVTRLYGDEK CCHHHHHHHHHCCHH	22.18	24894044
12	Phosphorylation	AEIVTRLYGDEKKLA HHHHHHHHCCHHHHC	21.17	24894044
179	Phosphorylation	SSENGVVSPDENKEL CCCCCCCCCCCCHHH	24.99	-
255	Phosphorylation	SIEVAAGTLSPLEKS CCHHHHEECCCCCCC	21.24	23776212
257	Phosphorylation	EVAAGTLSPLEKSSS HHHHEECCCCCCCCC	27.55	30291188
263	Phosphorylation	LSPLEKSSSEEKGET CCCCCCCCCCCCCCC	53.49	-
283	Phosphorylation	NGGHDIQSNKEIVKQ CCCCCCHHCHHHHHC	50.64	-
315	Phosphorylation	ERESEVLSSVSPTES HHHHHHHHCCCCCCC	33.59	25561503
316	Phosphorylation	RESEVLSSVSPTESR HHHHHHHCCCCCCCC	23.58	25561503
318	Phosphorylation	SEVLSSVSPTESRSD HHHHHCCCCCCCCCC	28.22	30291188
320	Phosphorylation	VLSSVSPTESRSDTA HHHCCCCCCCCCCCC	38.80	19880383
322	Phosphorylation	SSVSPTESRSDTAAL HCCCCCCCCCCCCCC	39.29	25561503
434	Phosphorylation	GSRVGAFSFDRASAM CCCCCCCCCHHHHHH	26.21	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TC120_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TC120_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TC120_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TI110_ARATH	TIC110	physical	15829604

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.