TBX15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBX15_HUMAN
• UniProt AC: Q96SF7
• Protein Name: T-box transcription factor TBX15
• Gene Name: TBX15
• Organism: Homo sapiens (Human).
• Sequence Length: 602
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity)..
• Protein Sequence: MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSMEALSPAGPLGDTEDAAAHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGPVPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDFTTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLCNLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTTSATQPSETFMPQRTPSLISGIPTPPSLPGNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPSGMEHSMHMISPSPNNQQATNTCDGRQYGAVPGSSSQMSVHMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSERRRSAVALSSR -CCHHHHHHHHHHCC	25.86	26437602
159	Phosphorylation	GLDPHQQYYIAMDIV CCCHHHCEEEEEEEE	7.11	-
173	Phosphorylation	VPVDNKRYRYVYHSS EECCCCEEEEEEECC	14.12	-
175	Phosphorylation	VDNKRYRYVYHSSKW CCCCEEEEEEECCCE	9.09	-
177	Phosphorylation	NKRYRYVYHSSKWMV CCEEEEEEECCCEEE	6.25	-
190	Phosphorylation	MVAGNADSPVPPRVY EEECCCCCCCCCEEE	25.95	29255136
224	Phosphorylation	DKLKLTNNELDDQGH EEEEECCCCCCCCCE	46.07	27251275
252	Phosphorylation	HVIRKDFSSDLSPTK EEEECCCCCCCCCCC	32.83	26852163
253	Phosphorylation	VIRKDFSSDLSPTKP EEECCCCCCCCCCCC	42.43	26852163
256	Phosphorylation	KDFSSDLSPTKPVPV CCCCCCCCCCCCEEC	35.20	24719451
258	Phosphorylation	FSSDLSPTKPVPVGD CCCCCCCCCCEECCC	44.60	26852163
305	Phosphorylation	FAKGFRDSGRNRTGL CHHCCCCCCCCHHHH	35.08	26437602
328	Phosphorylation	FWRPPVRTLTFEDFT HHCCCEEEEEHHHHC	30.31	23186163
330	Phosphorylation	RPPVRTLTFEDFTTM CCCEEEEEHHHHCCC	25.11	14702039
405	Phosphorylation	DYPPCARSNMAALQS CCCCCHHCCHHHHHH	16.66	27542207
412	Phosphorylation	SNMAALQSYPGLSDS CCHHHHHHCCCCCCC	33.86	27542207
413	Phosphorylation	NMAALQSYPGLSDSG CHHHHHHCCCCCCCC	6.59	27542207
417	Phosphorylation	LQSYPGLSDSGYNRL HHHCCCCCCCCCCCC	35.33	27542207
419	Phosphorylation	SYPGLSDSGYNRLQS HCCCCCCCCCCCCCC	39.54	27542207
421	Phosphorylation	PGLSDSGYNRLQSGT CCCCCCCCCCCCCCC	10.89	27542207
425	Phosphorylation	DSGYNRLQSGTTSAT CCCCCCCCCCCCCCC	36.26	-
531	Phosphorylation	TSPRLAASPEKLSAS CCHHCCCCHHHCCCC	28.16	26699800
587	Phosphorylation	NTCDGRQYGAVPGSS CCCCCCEECCCCCCC	12.99	23663014
593	Phosphorylation	QYGAVPGSSSQMSVH EECCCCCCCCCCEEE	22.27	23663014
594	Phosphorylation	YGAVPGSSSQMSVHM ECCCCCCCCCCEEEE	30.42	23663014
595	Phosphorylation	GAVPGSSSQMSVHMV CCCCCCCCCCEEEEC	31.44	23663014
598	Phosphorylation	PGSSSQMSVHMV--- CCCCCCCEEEEC---	10.96	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBX15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBX15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBX15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBX15_HUMAN	TBX15	physical	25416956
VENTX_HUMAN	VENTX	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.