SYT5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT5_HUMAN
• UniProt AC: O00445
• Protein Name: Synaptotagmin-5
• Gene Name: SYT5
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. In mast cells, localizes to the endocytic recycling compartment..
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity)..
• Protein Sequence: MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PGPPSPDTPPDSSRI CCCCCCCCCCCCCCC	39.85	-
19	Phosphorylation	SPDTPPDSSRISHGP CCCCCCCCCCCCCCC	27.56	-
20	Phosphorylation	PDTPPDSSRISHGPV CCCCCCCCCCCCCCC	40.80	-
59	Phosphorylation	RKSCRRRTGKKSQAQ HHHHHHHCCCCHHHH	52.09	-
81	Phosphorylation	VKGLGQSYIDKVQPE HHCCCHHHHHHHCCC	12.78	25884760
196	Phosphorylation	RVLVMAVYDFDRFSR EEEEEEEEECCCCCC	11.01	-
202	Phosphorylation	VYDFDRFSRNDAIGE EEECCCCCCCCCCCE	30.94	-
268	Acetylation	LEAKNLKKMDVGGLS EEECCCCCCCCCCCC	43.42	30592789
278	Phosphorylation	VGGLSDPYVKVHLLQ CCCCCCCCHHHEEEC	20.21	25884760
295	Ubiquitination	KKVRKKKTTIKKNTL CCCCCCCCCCCCCCC	42.50	-
299	Ubiquitination	KKKTTIKKNTLNPYY CCCCCCCCCCCCHHC	51.84	21906983
301	Phosphorylation	KTTIKKNTLNPYYNE CCCCCCCCCCHHCCC	36.47	28387310
305	Phosphorylation	KKNTLNPYYNEAFSF CCCCCCHHCCCCCEE	20.18	28387310
331	Phosphorylation	VELTVLDYDKLGKNE EEEEECCHHHCCCCC	15.71	28387310

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT5_HUMAN	SYT5	physical	10531343
VATC2_HUMAN	ATP6V1C2	physical	26186194
PALM2_HUMAN	PALM2	physical	26186194
SYT1_HUMAN	SYT1	physical	26186194
SYT1_HUMAN	SYT1	physical	28514442
VATC2_HUMAN	ATP6V1C2	physical	28514442
PALM2_HUMAN	PALM2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.