dbPTM

SYMPK_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYMPK_DROME
UniProt AC	Q8MSU4
Protein Name	Symplekin {ECO:0000312\|EMBL:AAF51962.2}
Gene Name	Sym
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1165
Subcellular Localization	Nucleus . Concentrates in the histone locus body.
Protein Description	Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA..
Protein Sequence	MDSIIGRSQFVSETANLFTDEKTATARAKVVDWCNELVIASPSTKCELLAKVQETVLGSCAELAEEFLESVLSLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACGSIYKNGLQYLCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQSFADEDSLKRDGDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVNLIACTSSLCTIAKMRPIFMGAVVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNRGAFEFASTIRGMLVDLGSSTNEIQKLIPKMDKQEMARRQKRILENAAQSLAKRARLACEQQDQQQREMELDTEELERQKQKSTRVNEKFLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISRFFGEQLSEKRLGPGAATFSREPPMRVKKVQAIESTLTAMEVDEDAVQKLSEEEFQRKEEATKKLRETMERAKGEQTVIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKGGVSSKRRKLVTVIAATFPDNVRYGIMEFILEDIKQRIDLAFSWLFEEYSLLQGFTRHTYVKTENRPDHAYNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELIKDLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQESPPAAVFSQDFGRPTEEPDWREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRSLDIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRVMIPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLGIGAEFAHQTMAMTPTDILVALHTIDTSVCDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLLQRLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDEPMNGSGITQQVLDIISGKSVDVFVTDESGGYISAEHIKKEAPDPSEISVISTVPVLTSLVPLPVPPPIGSDLNQPLPPGED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of SYMPK_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYMPK_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYMPK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYMPK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAD6_DROME	Ak6	physical	14605208
CPSF3_DROME	Cpsf73	physical	26081560
CPSF2_DROME	Cpsf100	physical	26081560

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYMPK_DROME

Related Literatures of Post-Translational Modification