CPSF2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPSF2_DROME
• UniProt AC: Q9V3D6
• Protein Name: Probable cleavage and polyadenylation specificity factor subunit 2
• Gene Name: Cpsf100
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 756
• Subcellular Localization: Nucleus .
• Protein Description: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA..
• Protein Sequence: MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHCEQNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAWVDGRLGMRVKAIEAPMDVTVEQDASVQEGKTLTLETLADDEIPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSNGTLALRRVDAGKVAMEGCLSEEYYKIRELLYEQYAIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
221	Phosphorylation	ARDEKLMTNILQTVR HHHHHHHHHHHHHHH	29.55	22817900
226	Phosphorylation	LMTNILQTVRNNGNV HHHHHHHHHHHCCCE	20.28	22817900
418	Phosphorylation	KPDVEEESSSESEDD CCCCCCCCCCCCCCC	42.30	19429919
419	Phosphorylation	PDVEEESSSESEDDI CCCCCCCCCCCCCCE	41.21	19429919
420	Phosphorylation	DVEEESSSESEDDIE CCCCCCCCCCCCCEE	55.19	19429919
422	Phosphorylation	EEESSSESEDDIEMS CCCCCCCCCCCEEEE	48.55	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPSF2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPSF2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPSF2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYMPK_DROME	Sym	physical	26081560
CPSF3_DROME	Cpsf73	physical	26081560

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-221 AND THR-226, ANDMASS SPECTROMETRY.
PubMed: 18327897