STXB2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STXB2_RAT
• UniProt AC: Q62753
• Protein Name: Syntaxin-binding protein 2
• Gene Name: Stxbp2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 594
• Protein Description: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity)..
• Protein Sequence: MAPLGLKAVVVEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIADFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAGERGRQLDVLAQQIATLCATLQEYPSIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLHIEQDTYRYETTGLSESREKAVLLDEDDDLWVELRHMHIADVSKKVTELLKTFCESKRLTTDKANIKDLSHILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCGVEQDLAMGSDAEGEKIKDTMKLIVPVLLDASVPPYDKIRVLLLYILLRNGVSEENLAKLIQHANVQSYSNLIRNLEQLGGTVTNSAGSGTSSRLERRERMEPTYQLSRWSPVIKDVMEDVVEDRLDRKLWPFVSDPAPVSSSQAAVSSARFGHWHKNKAGIEARAGPRLIVYIVGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLRTLDQKLEDIALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
216	Phosphorylation	LNAFKADTPSLGEGP HHCCCCCCCCCCCCC	21.45	30181290
418	Phosphorylation	ILLRNGVSEENLAKL HHHHCCCCHHHHHHH	40.36	27097102
433	Phosphorylation	IQHANVQSYSNLIRN HHHHCHHHHHHHHHH	26.67	27097102
434	Phosphorylation	QHANVQSYSNLIRNL HHHCHHHHHHHHHHH	5.63	27097102
435	Phosphorylation	HANVQSYSNLIRNLE HHCHHHHHHHHHHHH	30.33	27097102
587	Acetylation	DLRTLDQKLEDIALP HHHHHHHHHHHHCCC	54.21	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STXB2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STXB2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STXB2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX1A_RAT	Stx1a	physical	7768895
STX3_RAT	Stx3	physical	7768895

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.