STUB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STUB_DROME
• UniProt AC: Q05319
• Protein Name: Serine proteinase stubble
• Gene Name: Sb
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 787
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Hormone dependent protease required for epithelial morphogenesis, including the formation of bristles, legs, and wings. Has a dual function, detaches imaginal disk cells from extracellular matrices through its extracellular proteolytic domain and transmits an outside-to-inside signal to its intracellular domain to modify the cytoskeleton during morphogenesis..
• Protein Sequence: MKQPTLIRPRLRHRRSTPAAATKMCPKRHWLVNNRAAGSRGSGGAAARSRRSLDQIVEVLVALIVVNCLATAAAALITPPDSLESLGSLGIPSSSASSSEDDDDMSSGFYRIPHRLEGYPQLQQLQRGQNFKISPKPCSFGRVEGTCMFVWECIKSEGKHVGMCVDSFMFGSCCTHNYTDNIVLPQTAFSYTRPTKPLTLRPRPPAAPYKPMISGMTTIERPHGAGTLVIRPSGPHHQGTLARPHPPPYQSKPTTASDLHGSASHPSSSSSSSSSSNPNSIWHTSTQQQQQQQHQQNQQNHWQMTTEPSFITKPRPTGWTKPGIVNLPMPARPSKPSKPTKKPIVYDRTPPPPPSVPPSTSTSTTSTSLIWPAQTHPPQPHRPTRPQLSPGTSLAASSSSHWPSSTTSTTSSTTSTTTTTTTTRRTTTPTTTTRRTTTNKPTRPYQRPTTATSSSSTSTTSSKTPTTTRPISSSSSSSSGIVTSSQRPTQPTHRTPVLATSGIETNEISDSSIPDAGALGHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTHRCGGALINENWIATAGHCVDDLLISQIRIRVGEYDFSHVQEQLPYIERGVAKKVVHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGMNATVTGWGRLSEGGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDIFLCAGYETGGQDSCQGDSGGPLQAKSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	N-linked_Glycosylation	FGSCCTHNYTDNIVL CCCCCCCCCCCCEEE	24.20	-
466	Phosphorylation	TTSSKTPTTTRPISS CCCCCCCCCCCCCCC	46.13	22817900
467	Phosphorylation	TSSKTPTTTRPISSS CCCCCCCCCCCCCCC	23.24	22817900
468	Phosphorylation	SSKTPTTTRPISSSS CCCCCCCCCCCCCCC	36.61	22817900
475	Phosphorylation	TRPISSSSSSSSGIV CCCCCCCCCCCCCCE	35.87	22817900
484	Phosphorylation	SSSGIVTSSQRPTQP CCCCCEECCCCCCCC	17.36	22817900
485	Phosphorylation	SSGIVTSSQRPTQPT CCCCEECCCCCCCCC	22.35	22817900
672	N-linked_Glycosylation	DSLLIGMNATVTGWG CEEEECCCEEECCCE	27.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STUB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STUB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STUB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIMK1_DROME	LIMK1	genetic	14972681
RHO1_DROME	Rho1	genetic	14972681
RHO1_DROME	Rho1	genetic	14668391
MYSN_DROME	zip	genetic	14972681

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.