STAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAP1_HUMAN
• UniProt AC: Q9ULZ2
• Protein Name: Signal-transducing adaptor protein 1
• Gene Name: STAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Nucleus . Cytoplasm . Mitochondrion .
• Protein Description: In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC..
• Protein Sequence: MMAKKPPKPAPRRIFQERLKITALPLYFEGFLLIKRSGYREYEHYWTELRGTTLFFYTDKKSIIYVDKLDIVDLTCLTEQNSTEKNCAKFTLVLPKEEVQLKTENTESGEEWRGFILTVTELSVPQNVSLLPGQVIKLHEVLEREKKRRIETEQSTSVEKEKEPTEDYVDVLNPMPACFYTVSRKEATEMLQKNPSLGNMILRPGSDSRNYSITIRQEIDIPRIKHYKVMSVGQNYTIELEKPVTLPNLFSVIDYFVKETRGNLRPFICSTDENTGQEPSMEGRSEKLKKNPHIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	FQERLKITALPLYFE HHHHHCEEEECCEEE	22.13	-
27	Phosphorylation	KITALPLYFEGFLLI CEEEECCEEEEEEEE	9.54	-
42	Phosphorylation	KRSGYREYEHYWTEL ECCCCCCEEEEEEEE	10.06	-
45	Phosphorylation	GYREYEHYWTELRGT CCCCEEEEEEEECCC	11.33	-
57	Phosphorylation	RGTTLFFYTDKKSII CCCEEEEEECCCEEE	13.49	-
65	Phosphorylation	TDKKSIIYVDKLDIV ECCCEEEEEECCCEE	10.83	28064214
82	Phosphorylation	TCLTEQNSTEKNCAK EEECCCCCCCCCEEE	37.32	25627689
83	Phosphorylation	CLTEQNSTEKNCAKF EECCCCCCCCCEEEE	59.53	25627689
152	Phosphorylation	EKKRRIETEQSTSVE HHHHCCCCCCCCCCC	36.63	28634120
155	Phosphorylation	RRIETEQSTSVEKEK HCCCCCCCCCCCCCC	19.20	28634120
156	Phosphorylation	RIETEQSTSVEKEKE CCCCCCCCCCCCCCC	36.16	29449344
157	Phosphorylation	IETEQSTSVEKEKEP CCCCCCCCCCCCCCC	33.26	29449344
165	Phosphorylation	VEKEKEPTEDYVDVL CCCCCCCCCCHHHHH	42.45	27155012
168	Phosphorylation	EKEPTEDYVDVLNPM CCCCCCCHHHHHCCC	7.72	27155012
181	Phosphorylation	PMPACFYTVSRKEAT CCCCEEEEEEHHHHH	7.55	27762562
196	Phosphorylation	EMLQKNPSLGNMILR HHHHHCCCCCCCEEC	59.30	16964243
206	Phosphorylation	NMILRPGSDSRNYSI CCEECCCCCCCCEEE	34.79	30108239
208	Phosphorylation	ILRPGSDSRNYSITI EECCCCCCCCEEEEE	24.91	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3K1_HUMAN	SH3KBP1	physical	25416956
RETR3_HUMAN	FAM134C	physical	25416956
CD2AP_HUMAN	CD2AP	physical	26186194
ST1A1_HUMAN	SULT1A1	physical	26186194
SH3K1_HUMAN	SH3KBP1	physical	26186194
CAZA2_HUMAN	CAPZA2	physical	26186194
CAPZB_HUMAN	CAPZB	physical	26186194
SH3K1_HUMAN	SH3KBP1	physical	21516116
SH3K1_HUMAN	SH3KBP1	physical	28514442
CD2AP_HUMAN	CD2AP	physical	28514442
ST1A1_HUMAN	SULT1A1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND MASSSPECTROMETRY.
PubMed: 16964243