SRR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRR_HUMAN
• UniProt AC: Q9GZT4
• Protein Name: Serine racemase {ECO:0000303|PubMed:11054547}
• Gene Name: SRR
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Protein Description: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine..
• Protein Sequence: MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGVKSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MCAQYCISFADV ---CCCCEEEEHHHH	3.53	24043423
8	Phosphorylation	MCAQYCISFADVEKA CCCCEEEEHHHHHHH	15.72	24043423
45	Ubiquitination	TGRNLFFKCELFQKT CCCCCEEEEEEEECC	21.33	-
51	Ubiquitination	FKCELFQKTGSFKIR EEEEEEECCCCEEHH	47.74	-
56	N6-(pyridoxal phosphate)lysine	FQKTGSFKIRGALNA EECCCCEEHHHHHHH	32.94	-
56	Methylation	FQKTGSFKIRGALNA EECCCCEEHHHHHHH	32.94	1147570889
56	Other	FQKTGSFKIRGALNA EECCCCEEHHHHHHH	32.94	-
56	Ubiquitination	FQKTGSFKIRGALNA EECCCCEEHHHHHHH	32.94	-
66	Phosphorylation	GALNAVRSLVPDALE HHHHHHHHHCHHHHH	27.41	25003641
113	S-nitrosylation	VPQTAPDCKKLAIQA CCCCCCCHHHHHHHH	4.00	22178444
113	S-nitrosocysteine	VPQTAPDCKKLAIQA CCCCCCCHHHHHHHH	4.00	-
115	Ubiquitination	QTAPDCKKLAIQAYG CCCCCHHHHHHHHCC	49.86	-
134	Phosphorylation	YCEPSDESRENVAKR EECCCHHHHHHHHHH	50.30	-
205	Ubiquitination	KALKPSVKVYAAEPS EHHCCCCEEEECCCC	33.59	-
207	Phosphorylation	LKPSVKVYAAEPSNA HCCCCEEEECCCCCH	8.38	-
212	Phosphorylation	KVYAAEPSNADDCYQ EEEECCCCCHHHHHH	35.83	-
218	Phosphorylation	PSNADDCYQSKLKGK CCCHHHHHHHHHCCC	23.86	-
220	Phosphorylation	NADDCYQSKLKGKLM CHHHHHHHHHCCCCC	17.30	-
221	Ubiquitination	ADDCYQSKLKGKLMP HHHHHHHHHCCCCCC	38.40	-
223	Ubiquitination	DCYQSKLKGKLMPNL HHHHHHHCCCCCCCC	58.71	-
225	Ubiquitination	YQSKLKGKLMPNLYP HHHHHCCCCCCCCCC	39.77	-
231	Phosphorylation	GKLMPNLYPPETIAD CCCCCCCCCCHHHCH	24.31	20049867
242	Phosphorylation	TIADGVKSSIGLNTW HHCHHHHHHCCCCCH	25.45	-
320	Phosphorylation	SGGNVDLTSSITWVK ECCCEECCCEEEEEE	18.90	29978859
321	Phosphorylation	GGNVDLTSSITWVKQ CCCEECCCEEEEEEC	27.34	29978859
322	Phosphorylation	GNVDLTSSITWVKQA CCEECCCEEEEEECC	20.85	29978859
324	Phosphorylation	VDLTSSITWVKQAER EECCCEEEEEECCCC	26.59	29978859
339	Phosphorylation	PASYQSVSV------ CCCCCCCCC------	27.62	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRR_HUMAN	SRR	physical	12021263
GOGA3_HUMAN	GOLGA3	physical	16714286
A4_HUMAN	APP	physical	21832049
DISC1_HUMAN	DISC1	physical	22801410
DISC1_MOUSE	Disc1	physical	22801410
FBX22_HUMAN	FBXO22	physical	25336657

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00133: L-Serine