SPT13_HUMAN - dbPTM
SPT13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPT13_HUMAN
UniProt AC Q96N96
Protein Name Spermatogenesis-associated protein 13
Gene Name SPATA13
Organism Homo sapiens (Human).
Sequence Length 652
Subcellular Localization Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Protein Description Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression..
Protein Sequence MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQVPPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCPVAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSASPEDQ
------CCCCCHHHC		32.7625101063
3Phosphorylation-----MTSASPEDQN
-----CCCCCHHHCC		26.0025101063
5Phosphorylation---MTSASPEDQNAP
---CCCCCHHHCCCC		28.7025101063
26PhosphorylationARRRRPISVIGGVSL
CCCCCCEEEEECEEE		15.4620736484
43PhosphorylationTNQTEELDNLLTQPA
CCCHHHHHHHHCCCC		47.19-
44PhosphorylationNQTEELDNLLTQPAS
CCHHHHHHHHCCCCC		49.96-
55PhosphorylationQPASRPPMPAHQVPP
CCCCCCCCCHHHCCC		5.19-
68PhosphorylationPPYKAVSARFRPFTF
CCCCEEEECCCCCCC		14.1824719451
74PhosphorylationSARFRPFTFSQSTPI
EECCCCCCCCCCCCC		25.6723403867
76PhosphorylationRFRPFTFSQSTPIGL
CCCCCCCCCCCCCCC		21.8423403867
77PhosphorylationFRPFTFSQSTPIGLD
CCCCCCCCCCCCCCC		47.3224719451
78PhosphorylationRPFTFSQSTPIGLDR
CCCCCCCCCCCCCCH		34.6523401153
79PhosphorylationPFTFSQSTPIGLDRV
CCCCCCCCCCCCCHH		15.9928787133
83PhosphorylationSQSTPIGLDRVGRRR
CCCCCCCCCHHCHHH		3.83-
92PhosphorylationRVGRRRQMRASNVSS
HHCHHHHHHHCCCCC		3.5224719451
106PhosphorylationSDGGTEPSALVDDNG
CCCCCCCCEEECCCC		28.1826657352
114PhosphorylationALVDDNGSEEDFSYE
EEECCCCCCCCCCHH		44.0328348404
123SumoylationEDFSYEDLCQASPRY
CCCCHHHHHHCCCCC		1.23-
159PhosphorylationAEALWDHVTMDDQEL
HHHHHCCCCCCHHHH		4.3824719451
162PhosphorylationLWDHVTMDDQELGFK
HHCCCCCCHHHHCCC		45.1124719451
184PhosphorylationLEASNKDWWWGRSED
EHHCCCCCCCCCCCC		8.3724719451
211PhosphorylationRVNQEELSENSSSTP
EECHHHHHCCCCCCC		37.70-
214PhosphorylationQEELSENSSSTPSEE
HHHHHCCCCCCCCHH		22.93-
215PhosphorylationEELSENSSSTPSEEQ
HHHHCCCCCCCCHHH		50.22-
217PhosphorylationLSENSSSTPSEEQDE
HHCCCCCCCCHHHHH		32.5528985074
237UbiquitinationRHRHCENKQQMRTNV
HHHHHHHHHHHHHHH		21.44-
246PhosphorylationQMRTNVIREIMDTER
HHHHHHHHHHHHHCH		24.09-
249PhosphorylationTNVIREIMDTERVYI
HHHHHHHHHHCHHHH		4.46-
251PhosphorylationVIREIMDTERVYIKH
HHHHHHHHCHHHHHH		14.3329449344
252PhosphorylationIREIMDTERVYIKHL
HHHHHHHCHHHHHHH		35.57-
254PhosphorylationEIMDTERVYIKHLRD
HHHHHCHHHHHHHHH		4.7624719451
255PhosphorylationIMDTERVYIKHLRDI
HHHHCHHHHHHHHHH		15.52-
270PhosphorylationCEGYIRQCRKHTGMF
HHHHHHHHHHHCCCC		4.4924719451
271PhosphorylationEGYIRQCRKHTGMFT
HHHHHHHHHHCCCCH		26.00-
291PhosphorylationTIFGNIEDIYKFQRK
HHHCCHHHHHHHHHH		45.8027251275
302PhosphorylationFQRKFLKDLEKQYNK
HHHHHHHHHHHHHCC		63.31-
305PhosphorylationKFLKDLEKQYNKEEP
HHHHHHHHHHCCCCC		66.44-
310PhosphorylationLEKQYNKEEPHLSEI
HHHHHCCCCCCHHHH		73.4624719451
343PhosphorylationNNHPGACLELANLMK
CCCCCHHHHHHHHHH		6.3124719451
348PhosphorylationACLELANLMKQGKYR
HHHHHHHHHHCCCHH		3.6424719451
361PhosphorylationYRHFFEACRLLQQMI
HHHHHHHHHHHHHHH		2.19-
395UbiquitinationLQLAELLKYTTQEHG
HHHHHHHHHHCHHHC		53.85-
398PhosphorylationAELLKYTTQEHGDYS
HHHHHHHCHHHCCHH		28.9528152594
404PhosphorylationTTQEHGDYSNIKAAY
HCHHHCCHHHHHHHH		14.2828152594
405PhosphorylationTQEHGDYSNIKAAYE
CHHHCCHHHHHHHHH		36.5028152594
408UbiquitinationHGDYSNIKAAYEAMK
HCCHHHHHHHHHHHH		31.08-
411PhosphorylationYSNIKAAYEAMKNVA
HHHHHHHHHHHHHHH		14.74-
433PhosphorylationRKLESIDKIARWQVS
HHHHHHHHHHHHEEE		36.2724719451
453PhosphorylationGLDILDRSSELIHSG
CHHCCCCCCCCCHHC		28.03-
454PhosphorylationLDILDRSSELIHSGE
HHCCCCCCCCCHHCE		37.00-
464UbiquitinationIHSGELTKITKQGKS
CHHCEEEEEEECCCC		62.09-
471PhosphorylationKITKQGKSQQRTFFL
EEEECCCCCEEEEEE		38.0722210691
497PhosphorylationLLRRDMLYYKGRLDM
HHHCCCCHHCCCCCC		9.11-
498PhosphorylationLRRDMLYYKGRLDMD
HHCCCCHHCCCCCCC		11.73-
539PhosphorylationSRTTDEVYLFCAKKQ
HCCCCEEEEEEECCH		7.63-
561 (in isoform 6)Phosphorylation-40.8624719451
561PhosphorylationQACADERRRVQEDKE
HHHHHHHHHHHHHHH		40.8624719451
563PhosphorylationCADERRRVQEDKEMG
HHHHHHHHHHHHHHC		7.48-
563 (in isoform 6)Phosphorylation-7.4824275569
569 (in isoform 6)Phosphorylation-8.3628985074
574PhosphorylationKEMGMEISENQKKLA
HHHCCCCCHHHHHHH		19.7228796482
579UbiquitinationEISENQKKLAMLNAQ
CCCHHHHHHHHHHHH		31.54-
581PhosphorylationSENQKKLAMLNAQKA
CHHHHHHHHHHHHHH		14.8624719451
591PhosphorylationNAQKAGHGKSKGYNR
HHHHHCCCCCCCCCC		34.7124719451
591 (in isoform 6)Phosphorylation-34.7127251275
593 (in isoform 6)Phosphorylation-35.59-
593PhosphorylationQKAGHGKSKGYNRCP
HHHCCCCCCCCCCCC		35.59-
596PhosphorylationGHGKSKGYNRCPVAP
CCCCCCCCCCCCCCC		11.81-
598 (in isoform 6)Phosphorylation-20.0328122231
600PhosphorylationSKGYNRCPVAPPHQG
CCCCCCCCCCCCCCC		23.2827251275
600 (in isoform 6)Phosphorylation-23.2826657352
602PhosphorylationGYNRCPVAPPHQGLH
CCCCCCCCCCCCCCC		9.3227251275
602 (in isoform 6)Phosphorylation-9.3226657352
607PhosphorylationPVAPPHQGLHPIHQR
CCCCCCCCCCCCCCC		23.9527251275
607 (in isoform 6)Phosphorylation-23.9529523821
617PhosphorylationPIHQRHITMPTSVPQ
CCCCCCCCCCCCCCH		15.8028857561
620PhosphorylationQRHITMPTSVPQQQV
CCCCCCCCCCCHHHH		31.3728857561
621PhosphorylationRHITMPTSVPQQQVF
CCCCCCCCCCHHHHH		26.4028857561
627PhosphorylationTSVPQQQVFGLAEPK
CCCCHHHHHCCCCCC		3.41-
627 (in isoform 6)Phosphorylation-3.41-
630 (in isoform 6)Phosphorylation-3.1129507054
638PhosphorylationAEPKRKSSLFWHTFN
CCCCCHHHHHHHHHC		30.5328857561
703Phosphorylation----------------------------------------------------------
----------------------------------------------------------		24719451
739Phosphorylation----------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------		27251275
1246Phosphorylation-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		27251275
1263Phosphorylation------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPT13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPT13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPT13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433Z_HUMANYWHAZphysical
28514442
1433G_HUMANYWHAGphysical
28514442
1433E_HUMANYWHAEphysical
28514442
1433B_HUMANYWHABphysical
28514442
GCSP_HUMANGLDCphysical
28514442
1433F_HUMANYWHAHphysical
28514442
1433T_HUMANYWHAQphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPT13_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory