SPD5_CAEEL - dbPTM
SPD5_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPD5_CAEEL
UniProt AC P91349
Protein Name Spindle-defective protein 5
Gene Name spd-5
Organism Caenorhabditis elegans.
Sequence Length 1198
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Component of the centrosome. First expressed at two different foci in early postmeiotic one-cell stage embryos, prior to pronuclear migration but after the sperm-donated centriole d
Protein Description Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development..
Protein Sequence MEDNSVLNEDSNLEHVEGQPRRSMSQPVLNVEGDKRTSSTSATQQQVLSGAFSSADVRSIPIIQTWEENKALKTKITILRGELQMYQRRYSEAKEASQKRVKEVMDDYVDLKLGQENVQEKMEQYKLMEEDLLAMQSRIETSEDNFARQMKEFEAQKHAMEERIKELELSATDANNTTVGSFRGTLDDILKKNDPDFTLTSGYEERKINDLEAKLLSEIDKVAELEDHIQQLRQELDDQSARLADSENVRAQLEAATGQGILGAAGNAMVPNSTFMIGNGRESQTRDQLNYIDDLETKLADAKKENDKARQALVEYMNKCSKLEHEIRTMVKNSTFDSSSMLLGGQTSDELKIQIGKVNGELNVLRAENRELRIRCDQLTGGDGNLSISLGQSRLMAGIATNDVDSIGQGNETGGTSMRILPRESQLDDLEESKLPLMDTSSAVRNQQQFASMWEDFESVKDSLQNNHNDTLEGSFNSSMPPPGRDATQSFLSQKSFKNSPIVMQKPKSLHLHLKSHQSEGAGEQIQNNSFSTKTASPHVSQSHIPILHDMQQILDSSAMFLEGQHDVAVNVEQMQEKMSQIREALARLFERLKSSAALFEEILERMGSSDPNADKIKKMKLAFETSINDKLNVSAILEAAEKDLHNMSLNFSILEKSIVSQAAEASRRFTIAPDAEDVASSSLLNASYSPLFKFTSNSDIVEKLQNEVSELKNELEMARTRDMRSPLNGSSGRLSDVQINTNRMFEDLEVSEATLQKAKEENSTLKSQFAELEANLHQVNSKLGEVRCELNEALARVDGEQETRVKAENALEEARQLISSLKHEENELKKTITDMGMRLNEAKKSDEFLKSELSTALEEEKKSQNLADELSEELNGWRMRTKEAENKVEHASSEKSEMLERIVHLETEMEKLSTSEIAADYCSTKMTERKKEIELAKYREDFENAAIVGLERISKEISELTKKTLKAKIIPSNISSIQLVCDELCRRLSREREQQHEYAKVMRDVNEKIEKLQLEKDALEHELKMMSSNNENVPPVGTSVSGMPTKTSNQKCAQPHYTSPTRQLLHESTMAVDAIVQKLKKTHNMSGMGPELKETIGNVINESRVLRDFLHQKLILFKGIDMSNWKNETVDQLITDLGQLHQDNLMLEEQIKKYKKELKLTKSAIPTLGVEFQDRIKTEIGKIATDMGGAVKEIRKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationVEGQPRRSMSQPVLN
CCCCCCCCCCCCEEE		24.8628854356
25PhosphorylationGQPRRSMSQPVLNVE
CCCCCCCCCCEEEEE		32.3628854356
53PhosphorylationQVLSGAFSSADVRSI
HHHCCCCCCCCCCCC		24.8830078680
54PhosphorylationVLSGAFSSADVRSIP
HHCCCCCCCCCCCCC		23.2630078680
181PhosphorylationANNTTVGSFRGTLDD
CCCCCHHHHHHCHHH		13.8730078680
488PhosphorylationPPPGRDATQSFLSQK
CCCCCCHHHHHHHCH		29.0930078680
490PhosphorylationPGRDATQSFLSQKSF
CCCCHHHHHHHCHHH		24.6530078680
493PhosphorylationDATQSFLSQKSFKNS
CHHHHHHHCHHHCCC		33.2930078680
500PhosphorylationSQKSFKNSPIVMQKP
HCHHHCCCCEEECCC		19.3230078680
530PhosphorylationGEQIQNNSFSTKTAS
CHHCCCCCCCCCCCC		28.2921082442
626PhosphorylationKMKLAFETSINDKLN
HHHHHHHCCCCCCCC		28.5818806794
627PhosphorylationMKLAFETSINDKLNV
HHHHHHCCCCCCCCH		16.5230078680
635PhosphorylationINDKLNVSAILEAAE
CCCCCCHHHHHHHHH		14.4428854356
649PhosphorylationEKDLHNMSLNFSILE
HHHHHCCCCCHHHHH		26.0230078680
658PhosphorylationNFSILEKSIVSQAAE
CHHHHHHHHHHHHHH		20.8830078680
681PhosphorylationPDAEDVASSSLLNAS
CCHHHHHHHHHHCCC		21.9530078680
682PhosphorylationDAEDVASSSLLNASY
CHHHHHHHHHHCCCC		18.4430078680
683PhosphorylationAEDVASSSLLNASYS
HHHHHHHHHHCCCCC		34.0930078680
688PhosphorylationSSSLLNASYSPLFKF
HHHHHCCCCCCCCCC		25.6830078680
689PhosphorylationSSLLNASYSPLFKFT
HHHHCCCCCCCCCCC		16.3430078680
690PhosphorylationSLLNASYSPLFKFTS
HHHCCCCCCCCCCCC		16.7830078680
731PhosphorylationMRSPLNGSSGRLSDV
CCCCCCCCCCCCCEE		28.6618806794
732PhosphorylationRSPLNGSSGRLSDVQ
CCCCCCCCCCCCEEE		29.3619530675
736PhosphorylationNGSSGRLSDVQINTN
CCCCCCCCEEEECCC		34.0830078680
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPD5_CAEEL !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPD5_CAEEL !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPD5_CAEEL !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSN5_CAEELcsn-5physical
18692475
SPD5_CAEELspd-5physical
18692475
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPD5_CAEEL

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Related Literatures of Post-Translational Modification

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