SOCS7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS7_HUMAN
• UniProt AC: O14512
• Protein Name: Suppressor of cytokine signaling 7
• Gene Name: SOCS7
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7
• Protein Description: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)..
• Protein Sequence: MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
205	Phosphorylation	LRPLAGPSRKGSFKI CCCCCCCCCCCCEEE	45.78	29449344
207	Acetylation	PLAGPSRKGSFKIRL CCCCCCCCCCEEEEE	64.34	7822105
211	Methylation	PSRKGSFKIRLSRLF CCCCCCEEEEEEEEE	28.72	-
222	Phosphorylation	SRLFRTKSCNGGSGG EEEECCCCCCCCCCC	16.52	22210691
236	Methylation	GGDGTGKRPSGELAA CCCCCCCCCCHHHHH	31.77	30761103
238	Phosphorylation	DGTGKRPSGELAASA CCCCCCCCHHHHHHH	49.27	23532336
244	Phosphorylation	PSGELAASAASLTDM CCHHHHHHHHHHHCC	20.82	23532336
249	Phosphorylation	AASAASLTDMGGSAG HHHHHHHHCCCCHHH	22.80	22210691
254	Phosphorylation	SLTDMGGSAGRELDA HHHCCCCHHHCCCCC	23.09	24719451
307	Phosphorylation	LTSPHPPTPPPPPRR CCCCCCCCCCCCCCC	53.53	27080861
391	Phosphorylation	DSSSFAASLRELEKC CCCHHHHHHHHHHHH	25.24	23312004
421	Phosphorylation	LKGKPDGSFLVRDSS HCCCCCCCEEEECCC	23.84	20873877
437	Phosphorylation	PRYILSLSFRSQGIT CCEEEEEEEHHCCCC	18.42	24719451
447	Phosphorylation	SQGITHHTRMEHYRG HCCCCCCEEEEECCC	24.89	26546556
452	Phosphorylation	HHTRMEHYRGTFSLW CCEEEEECCCEEEEE	9.46	-
455	Phosphorylation	RMEHYRGTFSLWCHP EEEECCCEEEEEECH	10.89	-
457	Phosphorylation	EHYRGTFSLWCHPKF EECCCEEEEEECHHH	22.31	-
476	Acetylation	QSVVEFIKRAIMHSK HHHHHHHHHHHHHCC	40.89	7379869
489	Phosphorylation	SKNGKFLYFLRSRVP CCCCEEEEEECCCCC	12.05	27196784
507	Phosphorylation	PTPVQLLYPVSRFSN CCCHHHEEEHHHCCC	15.35	-
561	Phosphorylation	YDPQEEVYLSLKEAQ CCCHHHHEEEHHHHH	8.21	28152594
563	Phosphorylation	PQEEVYLSLKEAQLI CHHHHEEEHHHHHHH	21.51	28152594
571	Phosphorylation	LKEAQLISKQKQEVE HHHHHHHHHHHCCCC	37.31	24719451
580	Phosphorylation	QKQEVEPST------ HHCCCCCCC------	32.99	30631047
581	Phosphorylation	KQEVEPST------- HCCCCCCC-------	54.03	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCK1_HUMAN	NCK1	physical	9344857
VINEX_HUMAN	SORBS3	physical	15242778
STAT3_HUMAN	STAT3	physical	15677474
STA5A_HUMAN	STAT5A	physical	15677474
DAB1_HUMAN	DAB1	physical	24210661
CUL5_HUMAN	CUL5	physical	24210661

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.