| UniProt ID | SNTG1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NSN8 | |
| Protein Name | Gamma-1-syntrophin | |
| Gene Name | SNTG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 517 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. Nucleus. Mainly cytoplasmic and weakly nuclear. | |
| Protein Description | Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.. | |
| Protein Sequence | MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | PFYSGERTVTIRRQT CCCCCCCEEEEEEEE | 20.07 | 25278378 | |
| 59 | Phosphorylation | YSGERTVTIRRQTVG CCCCCEEEEEEEEEC | 14.25 | 24719451 | |
| 64 | Phosphorylation | TVTIRRQTVGGFGLS EEEEEEEEECCEEEE | 21.21 | 25278378 | |
| 71 | Phosphorylation | TVGGFGLSIKGGAEH EECCEEEEECCCHHH | 23.72 | 25278378 | |
| 137 | Phosphorylation | EEVTLTVSFLKRAPA CEEEEEEEHHHCCCC | 21.45 | 24719451 | |
| 434 | Phosphorylation | TKAVLWRYKFSQLKG HHHHHHHHHHHHCCC | 12.56 | 18083107 | |
| 440 | Acetylation | RYKFSQLKGSSDDGK HHHHHHCCCCCCCCC | 49.46 | 7826215 | |
| 447 | Acetylation | KGSSDDGKSKIKFLF CCCCCCCCHHEEEEE | 56.42 | 7826225 | |
| 447 | Ubiquitination | KGSSDDGKSKIKFLF CCCCCCCCHHEEEEE | 56.42 | - | |
| 449 | Acetylation | SSDDGKSKIKFLFQN CCCCCCHHEEEEEEC | 54.09 | 7826235 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNTG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNTG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNTG1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| STXB3_HUMAN | STXBP3 | physical | 12832401 | |
| VPS45_HUMAN | VPS45 | physical | 11062261 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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