SLX4_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLX4_DROME
• UniProt AC: Q9VS48
• Protein Name: Structure-specific endonuclease subunit SLX4
• Gene Name: mus312
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1145
• Subcellular Localization: Nucleus.
• Protein Description: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage (By similarity). Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). Interacts with the structure-specific MEI-9-ERCC1 endonuclease to generate meiotic crossovers..
• Protein Sequence: MDRKTRRANFKNLQPRLTRSTKAAADTLSLSNFFATPENAEEVPSCLADIPVQPDPPAPKIKPIRTSNVFEKPGPKPKKAPKLKASTVSTSSGARRGRGKSKQQPSISNFLRNEQIFAEVTAQHCMADNFSADDIEMALALSKSESEKHGRLRLHDDDDAVVDLLDDEEKSTERIRHKLQKYGFRTAAKEDYKSLAVLPVVASKGGRRGKWANRFTSLTLRNPDVQQKKLEEKVSALLGQEMRGKEPNGEDCCLTPYTVITAALKELRAEGESRILREPSEGPIDDLESYYVTDLFEVSRTPAHHLLKNWAAIQGRDFSPERETQKCRQLRQQHELVYAELERYYGDPQKLEEEVMQELDELEKLVADNMIEDDSVVINIVEAESSSTGSSPSKEPPDKRPKMTMEDKENLQPTTSKASLTVPAQSTRCTSPDLFADSEDEPDIVTTAISNEPEDVRNLSMKVYKNVSISERSSSVAEIEIVSSNDEPSQITTYEVFSSDEVKTVSNATQEKISFDDDFIDLTQEFDMVEFNESKPRTPNLIASSETDSNVDNLNGDTILDFSSQEVSCPISKELYAKYAKVETFPVWNAAAEEEDKIEFSLSMERDLKSSEQSSHQLGILTTPNDTEHSSSFSELNFSRNSLRRSVSLSTDLSFKSPLNWKMNSSAEKRVSPAASPYKQSDASVDLTQNSDDENDAILLSDEEINYSIWKGNKTVKDLDIGDDSSDSCFASPVTKKRAIPQFQTEEDLDAFLMDFSTDGNGSQGSHSPNKSALSKERAEFGILDAAPSQPFSLSELQSHADKEKSSDNEINWAEASFLDAPAKPLSRRSSHKFNELLAKISKPAHNSGDDFDEFDQMVFQSTKEAASSAGETSDMPQGLDLLLKGEIKTTAIPETRAPGNQTPIEPQQVDVDGNVYSVRVCHTPKPDFATLPESEILQQLYKYGIKPLKRKQAVKMLEFIYNQTHPIMKTAAVQDLPARSEPIVRSKSTPVIMERPHSQVAKSTSKTLKAIGTKKDLTFNDATGEELLRFSQSLAPSLCDDFETFVMQTNVTKKTPQPLVPLHIAWHNLICANPQLHESVLTYEPIDLQAVYLHLKHMGHRYDPKDLKTFFDRRCIIFRYELGAPGKQAERHVRRHTKKPSKRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
319	Phosphorylation	AIQGRDFSPERETQK HHCCCCCCHHHHHHH	30.09	22817900
672	Phosphorylation	SSAEKRVSPAASPYK CCCCCCCCCCCCCCC	16.92	22817900
676	Phosphorylation	KRVSPAASPYKQSDA CCCCCCCCCCCCCCC	30.76	22817900
831	Phosphorylation	KPLSRRSSHKFNELL CCCCCCCHHHHHHHH	28.96	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLX4_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLX4_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLX4_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPF_DROME	mei-9	physical	12504024
XPF_DROME	mei-9	physical	19595722
SLX1_DROME	slx1	physical	19595722
BLM_DROME	Blm	genetic	19595722

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.