| UniProt ID | SIX1_MOUSE | |
|---|---|---|
| UniProt AC | Q62231 | |
| Protein Name | Homeobox protein SIX1 | |
| Gene Name | Six1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 284 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2.. | |
| Protein Sequence | MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLTSSLVDLGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 204 | Phosphorylation | SNKQNQLSPLEGGKP CCCCCCCCCCCCCCC | 20.06 | 22210690 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIX1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIX1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIX1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SMRC2_MOUSE | Smarcc2 | physical | 22513373 | |
| SMRC2_MOUSE | Smarcc2 | genetic | 22513373 | |
| SOX2_MOUSE | Sox2 | genetic | 22513373 | |
| SMCA4_MOUSE | Smarca4 | genetic | 22513373 | |
| SMRC1_MOUSE | Smarcc1 | genetic | 22513373 | |
| SMCA4_MOUSE | Smarca4 | physical | 22513373 | |
| NDF1_MOUSE | Neurod1 | physical | 22513373 | |
| NGN1_MOUSE | Neurog1 | physical | 22513373 | |
| SOX2_MOUSE | Sox2 | physical | 22513373 | |
| SOX2_MOUSE | Sox2 | physical | 22340499 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
