SH3L3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3L3_HUMAN
• UniProt AC: Q9H299
• Protein Name: SH3 domain-binding glutamic acid-rich-like protein 3
• Gene Name: SH3BGRL3
• Organism: Homo sapiens (Human).
• Sequence Length: 93
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Could act as a modulator of glutaredoxin biological activity..
• Protein Sequence: MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKATPPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGLRVYST ------CCCCEEEEE	46.68	19413330
2	Phosphorylation	------MSGLRVYST ------CCCCEEEEE	46.68	27486199
5	Methylation	---MSGLRVYSTSVT ---CCCCEEEEEECC	28.93	115916841
7	Phosphorylation	-MSGLRVYSTSVTGS -CCCCEEEEEECCCC	10.37	28152594
8	Phosphorylation	MSGLRVYSTSVTGSR CCCCEEEEEECCCCH	16.02	28152594
9	Phosphorylation	SGLRVYSTSVTGSRE CCCEEEEEECCCCHH	14.99	28152594
10	Phosphorylation	GLRVYSTSVTGSREI CCEEEEEECCCCHHH	16.25	28152594
12	Phosphorylation	RVYSTSVTGSREIKS EEEEEECCCCHHHHC	29.25	21406692
14	Phosphorylation	YSTSVTGSREIKSQQ EEEECCCCHHHHCCC	19.85	25159151
18	Ubiquitination	VTGSREIKSQQSEVT CCCCHHHHCCCCEEE	37.14	23000965
18	Acetylation	VTGSREIKSQQSEVT CCCCHHHHCCCCEEE	37.14	25953088
19	Phosphorylation	TGSREIKSQQSEVTR CCCHHHHCCCCEEEH	38.83	29978859
22	Phosphorylation	REIKSQQSEVTRILD HHHHCCCCEEEHHHC	26.79	26699800
35	Phosphorylation	LDGKRIQYQLVDISQ HCCCEEEEEEEECCC	11.05	27642862
47	Methylation	ISQDNALRDEMRALA CCCCHHHHHHHHHHC	35.12	115916837
50	Sulfoxidation	DNALRDEMRALAGNP CHHHHHHHHHHCCCC	3.39	31801345
58	Ubiquitination	RALAGNPKATPPQIV HHHCCCCCCCCCCCC	69.74	29967540
60	Phosphorylation	LAGNPKATPPQIVNG HCCCCCCCCCCCCCC	41.44	29496963
70	Phosphorylation	QIVNGDQYCGDYELF CCCCCCCCCCCHHHH	11.79	26074081
74	Phosphorylation	GDQYCGDYELFVEAV CCCCCCCHHHHHHHH	10.38	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH3L3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3L3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3L3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UBP3_HUMAN	USP3	physical	22939629
STXB3_HUMAN	STXBP3	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.