SGIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGIP1_HUMAN
• UniProt AC: Q9BQI5
• Protein Name: SH3-containing GRB2-like protein 3-interacting protein 1
• Gene Name: SGIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 828
• Subcellular Localization: Membrane, clathrin-coated pit ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis..
• Protein Sequence: MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPHEPPYNSKAECAREGGKKVSKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGPVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPGPTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPPPTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22 (in isoform 5)	Phosphorylation	-	42.81	29514088
22 (in isoform 4)	Phosphorylation	-	42.81	29514088
22	Phosphorylation	IRKKEKDTDSTGSPD CCCCCCCCCCCCCCC	42.81	27732954
24 (in isoform 5)	Phosphorylation	-	36.44	26699800
24 (in isoform 4)	Phosphorylation	-	36.44	26699800
24	Phosphorylation	KKEKDTDSTGSPDRD CCCCCCCCCCCCCCC	36.44	27732954
25 (in isoform 5)	Phosphorylation	-	44.48	29514088
25 (in isoform 4)	Phosphorylation	-	44.48	29514088
25	Phosphorylation	KEKDTDSTGSPDRDG CCCCCCCCCCCCCCC	44.48	27732954
27	Phosphorylation	KDTDSTGSPDRDGIQ CCCCCCCCCCCCCCC	24.58	27732954
27 (in isoform 5)	Phosphorylation	-	24.58	29514088
27 (in isoform 4)	Phosphorylation	-	24.58	29514088
76	Phosphorylation	AEIDWERYNSPELDE EEEEHHHCCCCCCCC	14.42	27732954
78	Phosphorylation	IDWERYNSPELDEEG EEHHHCCCCCCCCCC	15.71	27732954
86	Phosphorylation	PELDEEGYSIRPEEP CCCCCCCCCCCCCCC	12.28	27732954
87	Phosphorylation	ELDEEGYSIRPEEPG CCCCCCCCCCCCCCC	23.99	24719451
95	Phosphorylation	IRPEEPGSTKGKHFY CCCCCCCCCCCCCCC	37.35	27732954
96	Phosphorylation	RPEEPGSTKGKHFYS CCCCCCCCCCCCCCC	50.13	27732954
102	Phosphorylation	STKGKHFYSSSESEE CCCCCCCCCCCCCHH	13.83	25307156
103	Phosphorylation	TKGKHFYSSSESEEE CCCCCCCCCCCCHHH	26.83	25307156
104	Phosphorylation	KGKHFYSSSESEEEE CCCCCCCCCCCHHHH	27.09	25307156
105	Phosphorylation	GKHFYSSSESEEEEE CCCCCCCCCCHHHHH	38.92	25307156
107	Phosphorylation	HFYSSSESEEEEESH CCCCCCCCHHHHHHH	52.86	25307156
113	Phosphorylation	ESEEEEESHKKFNIK CCHHHHHHHHHCCCE	43.84	30576142
118 (in isoform 4)	Phosphorylation	-	43.45	21712546
118 (in isoform 5)	Phosphorylation	-	43.45	21712546
125 (in isoform 5)	Phosphorylation	-	57.89	22199227
125 (in isoform 4)	Phosphorylation	-	57.89	22199227
126	Phosphorylation	IKIKPLQSKDILKNA CEECCCCCHHHHHHC	39.72	29507054
127 (in isoform 4)	Phosphorylation	-	35.51	22199227
127 (in isoform 5)	Phosphorylation	-	35.51	22199227
142	Phosphorylation	TVDELKASIGNIALS CHHHHHHHHCCEECC	29.46	24117733
149	Phosphorylation	SIGNIALSPSPVRKS HHCCEECCCCCCCCC	17.82	24117733
151	Phosphorylation	GNIALSPSPVRKSPR CCEECCCCCCCCCCC	32.43	24117733
156	Phosphorylation	SPSPVRKSPRRSPGA CCCCCCCCCCCCCCH	17.05	24117733
160	Phosphorylation	VRKSPRRSPGAIKRN CCCCCCCCCCHHHCC	29.03	22496350
169	Phosphorylation	GAIKRNLSSEEVARP CHHHCCCCHHHHCCC	38.97	25884760
170	Phosphorylation	AIKRNLSSEEVARPR HHHCCCCHHHHCCCC	40.73	23403867
179	Phosphorylation	EVARPRRSTPTPELI HHCCCCCCCCCHHHH	39.76	23403867
180	Phosphorylation	VARPRRSTPTPELIS HCCCCCCCCCHHHHC	29.39	23911959
182	Phosphorylation	RPRRSTPTPELISKK CCCCCCCCHHHHCCC	29.50	23403867
187	Phosphorylation	TPTPELISKKPPDDT CCCHHHHCCCCCCCC	47.45	27732954
227 (in isoform 5)	Phosphorylation	-	33.09	25921289
227 (in isoform 4)	Phosphorylation	-	33.09	25921289
231 (in isoform 4)	Phosphorylation	-	29.31	26699800
231 (in isoform 5)	Phosphorylation	-	29.31	26699800
233 (in isoform 5)	Phosphorylation	-	30.60	26699800
233 (in isoform 4)	Phosphorylation	-	30.60	26699800
233	Phosphorylation	SGQPINPSMESPKLT CCCCCCCCCCCCCCC	30.60	22199227
236 (in isoform 4)	Phosphorylation	-	20.77	27732954
236	Phosphorylation	PINPSMESPKLTRPF CCCCCCCCCCCCCCC	20.77	22199227
236 (in isoform 5)	Phosphorylation	-	20.77	27732954
240	Phosphorylation	SMESPKLTRPFPTGT CCCCCCCCCCCCCCC	42.28	26699800
242 (in isoform 4)	Phosphorylation	-	34.04	22617229
242 (in isoform 5)	Phosphorylation	-	34.04	22617229
243 (in isoform 4)	Phosphorylation	-	8.35	27732954
243 (in isoform 5)	Phosphorylation	-	8.35	27732954
245	Phosphorylation	KLTRPFPTGTPPPLP CCCCCCCCCCCCCCC	54.81	26699800
247	Phosphorylation	TRPFPTGTPPPLPPK CCCCCCCCCCCCCCC	34.79	28348404
249 (in isoform 4)	Phosphorylation	-	42.78	22617229
249 (in isoform 5)	Phosphorylation	-	42.78	22617229
259	Phosphorylation	PPKNVPATPPRTGSP CCCCCCCCCCCCCCC	27.96	22985185
263	Phosphorylation	VPATPPRTGSPLTIG CCCCCCCCCCCCEEC	48.03	26657352
265	Phosphorylation	ATPPRTGSPLTIGPG CCCCCCCCCCEECCC	19.00	20886841
268	Phosphorylation	PRTGSPLTIGPGNDQ CCCCCCCEECCCCCC	27.54	26657352
287	Phosphorylation	VKIEKLPSINDLDSI EEEEECCCCCCHHHC	44.45	24076635
293	Phosphorylation	PSINDLDSIFGPVLS CCCCCHHHCCCCCCC	27.41	29691806
300	Phosphorylation	SIFGPVLSPKSVAVN HCCCCCCCCCEEEEC	30.43	18510355
316	Phosphorylation	EEKWVHFSDTSPEHV EECEEECCCCCHHCC	25.71	20886841
318	Phosphorylation	KWVHFSDTSPEHVTP CEEECCCCCHHCCCC	45.01	18510355
319	Phosphorylation	WVHFSDTSPEHVTPE EEECCCCCHHCCCCC	33.03	20886841
324	Phosphorylation	DTSPEHVTPELTPRE CCCHHCCCCCCCCCC	16.98	27732954
328	Phosphorylation	EHVTPELTPREKVVS HCCCCCCCCCCCCCC	20.73	20044836
335	Phosphorylation	TPREKVVSPPATPDN CCCCCCCCCCCCCCC	28.31	20886841
339	Phosphorylation	KVVSPPATPDNPADS CCCCCCCCCCCCCCC	36.63	24076635
372	Phosphorylation	GPPRNVLSPLNLEEV CCCCCCCCCCCHHHH	24.06	19060867
399	Phosphorylation	DYLETISSPKDFGLG CHHHHCCCCCCCCCC	31.92	-
410	Phosphorylation	FGLGQRATPPPPPPP CCCCCCCCCCCCCCC	38.22	24076635
424	Phosphorylation	PTYRTVVSSPGPGSG CCEEEEECCCCCCCC	26.86	25332170
438	Phosphorylation	GPGPGTTSGASSPAR CCCCCCCCCCCCCCC	32.00	25332170
441	Phosphorylation	PGTTSGASSPARPAT CCCCCCCCCCCCCCC	40.14	24076635
442	Phosphorylation	GTTSGASSPARPATP CCCCCCCCCCCCCCC	23.26	24076635
448	Phosphorylation	SSPARPATPLVPCRS CCCCCCCCCCCCCCC	21.60	-
455	Phosphorylation	TPLVPCRSTTPPPPP CCCCCCCCCCCCCCC	43.26	25332170
456	Phosphorylation	PLVPCRSTTPPPPPP CCCCCCCCCCCCCCC	24.78	26699800
457	Phosphorylation	LVPCRSTTPPPPPPR CCCCCCCCCCCCCCC	34.74	26657352
467	Phosphorylation	PPPPRPPSRPKLPPG CCCCCCCCCCCCCCC	64.99	26657352
482	Phosphorylation	KPGVGDVSRPFSPPI CCCCCCCCCCCCCCC	38.69	26699800
486	Phosphorylation	GDVSRPFSPPIHSSS CCCCCCCCCCCCCCC	32.23	20886841
491	Phosphorylation	PFSPPIHSSSPPPIA CCCCCCCCCCCCCCC	32.98	20886841
492	Phosphorylation	FSPPIHSSSPPPIAP CCCCCCCCCCCCCCC	32.47	20886841
493	Phosphorylation	SPPIHSSSPPPIAPL CCCCCCCCCCCCCCC	44.43	20886841
545	Phosphorylation	FYLTFEGSSRGPSPL EEEEECCCCCCCCCC	15.06	27732954
546	Phosphorylation	YLTFEGSSRGPSPLT EEEECCCCCCCCCCC	52.71	27732954
550	Phosphorylation	EGSSRGPSPLTMGAQ CCCCCCCCCCCCCCC	35.05	27732954
553	Phosphorylation	SRGPSPLTMGAQDTL CCCCCCCCCCCCCCC	19.55	27732954
559	Phosphorylation	LTMGAQDTLPVAAAF CCCCCCCCCHHHHHH	22.38	27732954
813	Phosphorylation	VGAGYRFSLIKKRFA ECCCEEHHHHHHHHH	21.86	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITSN1_HUMAN	ITSN1	physical	20946875
REPS1_HUMAN	REPS1	physical	20946875

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.