UniProt ID | SESN3_HUMAN | |
---|---|---|
UniProt AC | P58005 | |
Protein Name | Sestrin-3 {ECO:0000305} | |
Gene Name | SESN3 {ECO:0000312|HGNC:HGNC:23060} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 492 | |
Subcellular Localization | Cytoplasm . | |
Protein Description | May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. [PubMed: 25263562 May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity] | |
Protein Sequence | MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
3 | Methylation | -----MNRGGGSPSA -----CCCCCCCHHH | 43.78 | 115385979 | |
7 | Phosphorylation | -MNRGGGSPSAAANY -CCCCCCCHHHHHHH | 20.96 | 22617229 | |
9 | Phosphorylation | NRGGGSPSAAANYLL CCCCCCHHHHHHHHH | 32.03 | 28857561 | |
14 | Phosphorylation | SPSAAANYLLCTNCR CHHHHHHHHHCCCHH | 9.05 | 27080861 | |
33 | Phosphorylation | KDKRIRVSQPLTRGP CCCCEEECCCCCCCC | 19.07 | 28258704 | |
37 | Phosphorylation | IRVSQPLTRGPSAFI EEECCCCCCCCCCCC | 40.02 | 28258704 | |
41 | Phosphorylation | QPLTRGPSAFIPEKE CCCCCCCCCCCCHHH | 38.34 | 27174698 | |
47 | Ubiquitination | PSAFIPEKEVVQANT CCCCCCHHHEEECCC | 50.91 | 30230243 | |
54 | Phosphorylation | KEVVQANTVDERTNF HHEEECCCCCHHHCE | 32.14 | 27174698 | |
80 | Phosphorylation | DNITQVMSLHTQYLE CHHHHHHHHHHHHHH | 20.38 | 26552605 | |
83 | Phosphorylation | TQVMSLHTQYLESFL HHHHHHHHHHHHHHH | 24.97 | 26552605 | |
85 | Phosphorylation | VMSLHTQYLESFLRS HHHHHHHHHHHHHHH | 17.37 | 26552605 | |
88 | Phosphorylation | LHTQYLESFLRSQFY HHHHHHHHHHHHCHH | 27.30 | 26552605 | |
98 | Methylation | RSQFYMLRMDGPLPL HHCHHHHHCCCCCCC | 12.48 | 115385985 | |
153 | Ubiquitination | EYVPQRLKNLNEINK HCHHHHHHCHHHHHH | 62.67 | 32142685 | |
171 | Ubiquitination | HRPWLITKEHIQKLV CCCCCCCHHHHHHHH | 40.06 | 29967540 | |
176 | Ubiquitination | ITKEHIQKLVKTGEN CCHHHHHHHHHCCCC | 55.43 | 32142685 | |
239 | Ubiquitination | FCVCDLANDNNIENA EEEEECCCCCCCCCC | 60.90 | 21890473 | |
239 | Ubiquitination | FCVCDLANDNNIENA EEEEECCCCCCCCCC | 60.90 | 21890473 | |
282 | Phosphorylation | EREDEEASQEEMSTR HHHHHHHHHHHHHHH | 41.21 | - | |
287 | Phosphorylation | EASQEEMSTRFEKEK HHHHHHHHHHHHHHH | 21.51 | - | |
288 | Phosphorylation | ASQEEMSTRFEKEKK HHHHHHHHHHHHHHC | 37.76 | - | |
295 | Ubiquitination | TRFEKEKKESLFVVS HHHHHHHCCCEEEEE | 54.34 | 23000965 | |
299 | Ubiquitination | KEKKESLFVVSGDTF HHHCCCEEEEECCCC | 7.69 | 23000965 | |
355 | Ubiquitination | TFRAQDYTWENHGFS CCCCCCCCHHHCCHH | 34.29 | 21890473 | |
378 | Ubiquitination | IGHLLDEKFRMVYNL HHHHHCHHHHHHEEE | 37.63 | 23000965 | |
378 (in isoform 1) | Ubiquitination | - | 37.63 | 21890473 | |
411 | Ubiquitination | ALFNYVHCMFGIRYD HHHHHHHHHHCCCCC | 1.40 | 23000965 | |
415 | Ubiquitination | YVHCMFGIRYDDYDY HHHHHHCCCCCCCCH | 2.23 | 23000965 | |
434 | Ubiquitination | QLLERSLKVYIKTVT HHHHHHHHEEEEEEE | 33.95 | 23000965 | |
438 | Ubiquitination | RSLKVYIKTVTCYPE HHHHEEEEEEECCCC | 21.18 | 23000965 | |
439 | Phosphorylation | SLKVYIKTVTCYPER HHHEEEEEEECCCCC | 16.10 | 22964224 | |
443 | Phosphorylation | YIKTVTCYPERTTKR EEEEEECCCCCCCHH | 9.96 | 22964224 | |
447 | Phosphorylation | VTCYPERTTKRMYDS EECCCCCCCHHHHHH | 34.70 | - | |
454 | Phosphorylation | TTKRMYDSYWRQFKH CCHHHHHHHHHHCCC | 14.76 | - | |
455 | Phosphorylation | TKRMYDSYWRQFKHS CHHHHHHHHHHCCCC | 11.17 | - | |
482 | Phosphorylation | RMQAELLYALRAITR HHHHHHHHHHHHHHH | 19.06 | 24719451 | |
488 | Phosphorylation | LYALRAITRHLT--- HHHHHHHHHHCC--- | 15.85 | 24719451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SESN3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SESN3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SESN3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ZFP1_HUMAN | ZFP1 | physical | 26186194 | |
MYCB2_HUMAN | MYCBP2 | physical | 26186194 | |
ZFP1_HUMAN | ZFP1 | physical | 28514442 | |
MYCB2_HUMAN | MYCBP2 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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