SESN3_HUMAN - dbPTM
SESN3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SESN3_HUMAN
UniProt AC P58005
Protein Name Sestrin-3 {ECO:0000305}
Gene Name SESN3 {ECO:0000312|HGNC:HGNC:23060}
Organism Homo sapiens (Human).
Sequence Length 492
Subcellular Localization Cytoplasm .
Protein Description May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. [PubMed: 25263562 May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity]
Protein Sequence MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Methylation-----MNRGGGSPSA
-----CCCCCCCHHH		43.78115385979
7Phosphorylation-MNRGGGSPSAAANY
-CCCCCCCHHHHHHH		20.9622617229
9PhosphorylationNRGGGSPSAAANYLL
CCCCCCHHHHHHHHH		32.0328857561
14PhosphorylationSPSAAANYLLCTNCR
CHHHHHHHHHCCCHH		9.0527080861
33PhosphorylationKDKRIRVSQPLTRGP
CCCCEEECCCCCCCC		19.0728258704
37PhosphorylationIRVSQPLTRGPSAFI
EEECCCCCCCCCCCC		40.0228258704
41PhosphorylationQPLTRGPSAFIPEKE
CCCCCCCCCCCCHHH		38.3427174698
47UbiquitinationPSAFIPEKEVVQANT
CCCCCCHHHEEECCC		50.9130230243
54PhosphorylationKEVVQANTVDERTNF
HHEEECCCCCHHHCE		32.1427174698
80PhosphorylationDNITQVMSLHTQYLE
CHHHHHHHHHHHHHH		20.3826552605
83PhosphorylationTQVMSLHTQYLESFL
HHHHHHHHHHHHHHH		24.9726552605
85PhosphorylationVMSLHTQYLESFLRS
HHHHHHHHHHHHHHH		17.3726552605
88PhosphorylationLHTQYLESFLRSQFY
HHHHHHHHHHHHCHH		27.3026552605
98MethylationRSQFYMLRMDGPLPL
HHCHHHHHCCCCCCC		12.48115385985
153UbiquitinationEYVPQRLKNLNEINK
HCHHHHHHCHHHHHH		62.6732142685
171UbiquitinationHRPWLITKEHIQKLV
CCCCCCCHHHHHHHH		40.0629967540
176UbiquitinationITKEHIQKLVKTGEN
CCHHHHHHHHHCCCC		55.4332142685
239UbiquitinationFCVCDLANDNNIENA
EEEEECCCCCCCCCC		60.9021890473
239UbiquitinationFCVCDLANDNNIENA
EEEEECCCCCCCCCC		60.9021890473
282PhosphorylationEREDEEASQEEMSTR
HHHHHHHHHHHHHHH		41.21-
287PhosphorylationEASQEEMSTRFEKEK
HHHHHHHHHHHHHHH		21.51-
288PhosphorylationASQEEMSTRFEKEKK
HHHHHHHHHHHHHHC		37.76-
295UbiquitinationTRFEKEKKESLFVVS
HHHHHHHCCCEEEEE		54.3423000965
299UbiquitinationKEKKESLFVVSGDTF
HHHCCCEEEEECCCC		7.6923000965
355UbiquitinationTFRAQDYTWENHGFS
CCCCCCCCHHHCCHH		34.2921890473
378UbiquitinationIGHLLDEKFRMVYNL
HHHHHCHHHHHHEEE		37.6323000965
378 (in isoform 1)Ubiquitination-37.6321890473
411UbiquitinationALFNYVHCMFGIRYD
HHHHHHHHHHCCCCC		1.4023000965
415UbiquitinationYVHCMFGIRYDDYDY
HHHHHHCCCCCCCCH		2.2323000965
434UbiquitinationQLLERSLKVYIKTVT
HHHHHHHHEEEEEEE		33.9523000965
438UbiquitinationRSLKVYIKTVTCYPE
HHHHEEEEEEECCCC		21.1823000965
439PhosphorylationSLKVYIKTVTCYPER
HHHEEEEEEECCCCC		16.1022964224
443PhosphorylationYIKTVTCYPERTTKR
EEEEEECCCCCCCHH		9.9622964224
447PhosphorylationVTCYPERTTKRMYDS
EECCCCCCCHHHHHH		34.70-
454PhosphorylationTTKRMYDSYWRQFKH
CCHHHHHHHHHHCCC		14.76-
455PhosphorylationTKRMYDSYWRQFKHS
CHHHHHHHHHHCCCC		11.17-
482PhosphorylationRMQAELLYALRAITR
HHHHHHHHHHHHHHH		19.0624719451
488PhosphorylationLYALRAITRHLT---
HHHHHHHHHHCC---		15.8524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SESN3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SESN3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SESN3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZFP1_HUMANZFP1physical
26186194
MYCB2_HUMANMYCBP2physical
26186194
ZFP1_HUMANZFP1physical
28514442
MYCB2_HUMANMYCBP2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SESN3_HUMAN

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Related Literatures of Post-Translational Modification

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