SEM4A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM4A_MOUSE
• UniProt AC: Q62178
• Protein Name: Semaphorin-4A
• Gene Name: Sema4a
• Organism: Mus musculus (Mouse).
• Sequence Length: 760
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons..
• Protein Sequence: MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKYHAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFMKDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQDSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKDHRTSASDVDADNNHLGAEVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	N-linked_Glycosylation	CAFKKKSNETQCFNF EEEECCCCCCHHHHH	66.28	-
135	N-linked_Glycosylation	IRVLVSYNATHLYAC HHHHHHCCCCEEEEC	30.75	-
496	N-linked_Glycosylation	IWRVPRANCSVYESC CCCCCCCCCCCHHHH	21.63	-
606	N-linked_Glycosylation	EASATVYNGSLLLLP CCEEEEECCEEEEEE	29.28	-
718	S-palmitoylation	ARGKVQGCGMLPPRE HCCCCCCCCCCCCHH	1.29	28680068
730	Phosphorylation	PREKAPLSRDQHLQP CHHCCCCCCCCCCCC	32.52	29899451
738	Phosphorylation	RDQHLQPSKDHRTSA CCCCCCCCCCCCCCH	37.44	25266776
743	Phosphorylation	QPSKDHRTSASDVDA CCCCCCCCCHHHCCC	25.81	21082442
744	Phosphorylation	PSKDHRTSASDVDAD CCCCCCCCHHHCCCC	26.23	25521595
746	Phosphorylation	KDHRTSASDVDADNN CCCCCCHHHCCCCCC	37.62	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM4A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM4A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM4A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP_MOUSE	Psap	physical	22465952
OPTN_MOUSE	Optn	physical	22465952
RB11A_MOUSE	Rab11a	physical	22465952
RLBP1_MOUSE	Rlbp1	physical	22465952
RET1_MOUSE	Rbp1	physical	22465952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-743 AND SER-746, ANDMASS SPECTROMETRY.
PubMed: 17242355