SD18_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SD18_ARATH
• UniProt AC: O81905
• Protein Name: Receptor-like serine/threonine-protein kinase SD1-8
• Gene Name: SD18
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 850
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in the regulation of cellular expansion and differentiation..
• Protein Sequence: MRGLPNFYHSYTFFFFFLLILFPAYSISANTLSASESLTISSNNTIVSPGNVFELGFFKPGLDSRWYLGIWYKAISKRTYVWVANRDTPLSSSIGTLKISDSNLVVLDQSDTPVWSTNLTGGDVRSPLVAELLDNGNFVLRDSKNSAPDGVLWQSFDFPTDTLLPEMKLGWDAKTGFNRFIRSWKSPDDPSSGDFSFKLETEGFPEIFLWNRESRMYRSGPWNGIRFSGVPEMQPFEYMVFNFTTSKEEVTYSFRITKSDVYSRLSISSSGLLQRFTWIETAQNWNQFWYAPKDQCDEYKECGVYGYCDSNTSPVCNCIKGFKPRNPQVWGLRDGSDGCVRKTLLSCGGGDGFVRLKKMKLPDTTTASVDRGIGVKECEQKCLRDCNCTAFANTDIRGSGSGCVTWTGELFDIRNYAKGGQDLYVRLAATDLEDKRNRSAKIIGSSIGVSVLLLLSFIIFFLWKRKQKRSILIETPIVDHQLRSRDLLMNEVVISSRRHISRENNTDDLELPLMEFEEVAMATNNFSNANKLGQGGFGIVYKGKLLDGQEMAVKRLSKTSVQGTDEFKNEVKLIARLQHINLVRLLACCVDAGEKMLIYEYLENLSLDSHLFDKSRNSKLNWQMRFDIINGIARGLLYLHQDSRFRIIHRDLKASNILLDKYMTPKISDFGMARIFGRDETEANTRKVVGTYGYMSPEYAMDGIFSMKSDVFSFGVLLLEIISSKRNKGFYNSDRDLNLLGCVWRNWKEGKGLEIIDPIITDSSSTFRQHEILRCIQIGLLCVQERAEDRPTMSLVILMLGSESTTIPQPKAPGYCLERSLLDTDSSSSKQRDDESWTVNQITVSVLDAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	N-linked_Glycosylation	ESLTISSNNTIVSPG CCEEECCCCEEECCC	42.76	-
118	N-linked_Glycosylation	DTPVWSTNLTGGDVR CCCCEEECCCCCCCC	30.04	-
196	Phosphorylation	DPSSGDFSFKLETEG CCCCCCCEEEEEECC	26.64	23572148
242	N-linked_Glycosylation	PFEYMVFNFTTSKEE CEEEEEEEECCCCCE	23.19	-
387	N-linked_Glycosylation	QKCLRDCNCTAFANT HHHHHHCCCCEEECC	30.39	-
437	N-linked_Glycosylation	TDLEDKRNRSAKIIG CCCHHHHCHHHHHHH	48.26	-
495	Phosphorylation	LMNEVVISSRRHISR HHHHHHHHCCCCCCC	13.24	15308754
496	Phosphorylation	MNEVVISSRRHISRE HHHHHHHCCCCCCCC	23.39	15308754
681	Phosphorylation	RIFGRDETEANTRKV CHHCCCCCHHHHCEE	44.69	25561503
685	Phosphorylation	RDETEANTRKVVGTY CCCCHHHHCEEEEEE	38.63	25561503
827	Phosphorylation	SLLDTDSSSSKQRDD HCCCCCCCCCCCCCC	41.25	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SD18_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SD18_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SD18_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUB38_ARATH	PUB38	physical	18552232
PUB9_ARATH	PUB9	physical	18552232
PUB14_ARATH	PUB14	physical	18552232
PUB13_ARATH	PUB13	physical	18552232
PUB45_ARATH	PUB45	physical	18552232
PUB29_ARATH	PUB29	physical	18552232
PUB44_ARATH	SAUL1	physical	18552232
CNG13_ARATH	CNGC13	physical	22737156
GCL1_ARATH	GCL1	physical	22737156
PUP3_ARATH	PUP3	physical	22737156

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.
PubMed: 14506206