SCG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCG3_HUMAN
• UniProt AC: Q8WXD2
• Protein Name: Secretogranin-3
• Gene Name: SCG3
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragr
• Protein Sequence: MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	SLHNRELSAERPLNE CHHHHHHHCCCCHHH	24.27	26657352
144	O-linked_Glycosylation	GLHQLDGTPLTAEDI CCCCCCCCCCCHHHH	18.13	55832661
170	Ubiquitination	NDRAVFDKIVSKLLN CCHHHHHHHHHHHHH	33.28	32142685
208	Phosphorylation	ISKEANNYEEDPNKP HHHHHHCCCCCCCCC	22.09	22817900
216	O-linked_Glycosylation	EEDPNKPTSWTENQA CCCCCCCCCCCCCCC	38.21	23234360
231	O-linked_Glycosylation	GKIPEKVTPMAAIQD CCCCCCCCCCHHHHC	20.58	23234360
294	Ubiquitination	IDSEKEAKEKETLIT CCCHHHHHHHHHHHH	71.11	-
301	Phosphorylation	KEKETLITIMKTLID HHHHHHHHHHHHHHH	20.38	22210691
305	Phosphorylation	TLITIMKTLIDFVKM HHHHHHHHHHHHHHH	16.15	22210691
320	Phosphorylation	MVKYGTISPEEGVSY HHHHCCCCHHHCCHH	26.54	-
359	Phosphorylation	SKLFPAPSEKSHEET HHHCCCCCCCCCCCC	60.82	26657352
359	O-linked_Glycosylation	SKLFPAPSEKSHEET HHHCCCCCCCCCCCC	60.82	55824849
362	Phosphorylation	FPAPSEKSHEETDST CCCCCCCCCCCCCCH	31.89	27732954
366	Phosphorylation	SEKSHEETDSTKEEA CCCCCCCCCCHHHHH	32.06	27732954
368	Phosphorylation	KSHEETDSTKEEAAK CCCCCCCCHHHHHHH	49.12	27732954
369	Phosphorylation	SHEETDSTKEEAAKM CCCCCCCHHHHHHHH	45.33	27732954
382	Phosphorylation	KMEKEYGSLKDSTKD HHHHHHCCCCCCCCC	31.20	28060719
386	Phosphorylation	EYGSLKDSTKDDNSN HHCCCCCCCCCCCCC	35.45	-
397	Acetylation	DNSNPGGKTDEPKGK CCCCCCCCCCCCCCH	59.73	7678649

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRGQ_HUMAN	IRGQ	physical	28514442
MRE11_HUMAN	MRE11A	physical	28514442
CGL_HUMAN	CTH	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.