dbPTM

SAS6_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAS6_CAEEL
UniProt AC	O62479
Protein Name	Spindle assembly abnormal protein 6
Gene Name	sas-6 {ECO:0000312\|WormBase:Y45F10D.9}
Organism	Caenorhabditis elegans.
Sequence Length	492
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localizes to centrioles, zyg-1 and sas-5 are required for centriole localization.
Protein Description	Central scaffolding component of the centrioles ensuring their 9-fold symmetry. [PubMed: 15572125 Required for centrosome biogenesis and duplication]
Protein Sequence	MTSKIALFDQTLIASLLQPLSLNQPDFKAYKTKVKLKISEQRNETSGEKELKFEISRSDDFEFLFSETLNNEKYQILARDHDLTVDFDAFPKVIIQHLLCKNIVKNLEEDGEVDARKKAGYHSIADPGKPTEINIILDAEKNFCSFELFSKTPISKGKIFSIKLHAVRGDHLISHLLKICSSQAVKLSTFYKSADELASLRQKCGDLEKQVEKLSGVKEEFEEMSEKFKELEDEVELVKEERENIRLLVEDKEDEVADLKQDTESLQKQLEENQEELEIVGNMLREEQGKVDQLQKRNVAHQKEIGKLRAELGTAQRNLEKADQLLKRNSQQQNQQSLDMRKLGELEADLKEKDSMVESLTETIGILRKELENEKLKAAENMDSFEKLSMENENLKEKIAHYRAQRFSPAPSGLPGLQTGLTNRLTPSFKPVLGPHTPYGANLNSRTPFRDNTTLNFQNSTIATPHAFRFNSQLIADETTGSSVTNTPPAQR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
408	Phosphorylation	HYRAQRFSPAPSGLP HHHHHHCCCCCCCCC	23.49	30078680
479	Phosphorylation	SQLIADETTGSSVTN CEEEECCCCCCCCCC	36.68	30078680
480	Phosphorylation	QLIADETTGSSVTNT EEEECCCCCCCCCCC	32.78	30078680
485	Phosphorylation	ETTGSSVTNTPPAQR CCCCCCCCCCCCCCC	35.01	30078680
487	Phosphorylation	TGSSVTNTPPAQR-- CCCCCCCCCCCCC--	22.68	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAS6_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAS6_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAS6_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAS5_CAEEL	sas-5	physical	23064147
SAS6_CAEEL	sas-6	physical	23064147
SAS5_CAEEL	sas-5	physical	18692475

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAS6_CAEEL

Related Literatures of Post-Translational Modification