SAS5_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAS5_CAEEL
• UniProt AC: Q20010
• Protein Name: Spindle assembly abnormal protein 5
• Gene Name: sas-5
• Organism: Caenorhabditis elegans.
• Sequence Length: 404
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localizes to centrioles. Shuttles between centrioles and the cytoplasm throughout the cell cycle. Requires zyg-1 and dephosphorylation by the PP2A complex for c
• Protein Description: Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis..
• Protein Sequence: MNNYDDLPCSIYFKKPTVQEFVDQPRVFEDSEVPAFQEVLQLPQERTKPPVPSTQPIVAAVEVAKKKSCLSAPKPRKEPPSHPALRQKTVAFGKTVNVSQTVEGTSRNSKKVLASTMSAQNTTTTEEQAAENWRDAMKTELQTIRTEIQEETARRQEELNAQNLVKMQELMSNFFQKITIPKQQAIEPVEKDKENFHESPRQSRQQKPASKIASAREVIKRDGVIPPEALTIIEQRLRSDPMFRQQIDNVLADAECDANRAAYSPPPPMSEVRYGSGVNPALMRETLTVERSIRYDNGLASIDSRQWTNERRDNRAPDSYRTYEPDQPCHSLYQKGQSISYYPSEAAGKTTARNNRTGYYVEDSSDHEEDVVVNKRGQNYHEQAVPETPAERERRIREKYARRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
199	Phosphorylation	DKENFHESPRQSRQQ HHCCCCCCCCHHHHC	19.47	30078680
263	Phosphorylation	CDANRAAYSPPPPMS CCCCCCCCCCCCCHH	22.26	30078680
264	Phosphorylation	DANRAAYSPPPPMSE CCCCCCCCCCCCHHH	26.63	30078680
364	Phosphorylation	TGYYVEDSSDHEEDV CEEEECCCCCCCCCE	24.94	30078680
365	Phosphorylation	GYYVEDSSDHEEDVV EEEECCCCCCCCCEE	56.14	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAS5_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAS5_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAS5_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAS6_CAEEL	sas-6	physical	23064147
SAS5_CAEEL	sas-5	physical	23064147
SAS5_CAEEL	sas-5	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.