SAS4_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAS4_CAEEL
• UniProt AC: P34402
• Protein Name: Spindle assembly abnormal protein 4
• Gene Name: sas-4
• Organism: Caenorhabditis elegans.
• Sequence Length: 808
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the centrosome throughout the cell cycle. Localizes to a tiny dot in the center of centrosome. Recruited to the centrosome once per cell cycle, at the time of organelle
• Protein Description: Required for centrosome duplication. Plays a central role in determining centrosome size..
• Protein Sequence: MASDENIGADGEQKPSRPFLRKGQGTARFRMPRNNKTSAGAPPTSELSSASSPSINVPRFSLSNALPNSARTVDSGISNEDETRPPTTASLPMDQPSLSSSPENRLNPAPSVAEEHGHSGQHAEEEEDNDTDEVSAMPSFVPDEPSTLVNSDHELSDDALKYKNAAAEFKAFERRMDSMRSASTITTSLATPSSCAPSNSSEPPTRSTPIMNDLGVGPNNHNWPSSMQELSGISLETPQARPLGSNRINQLVRSEAQTGISLLQHHERPTVTAPLRRNDMMNSSRQNPQNGNVQDENRPEHVYDQPIHVPGSSLDRQKLEIEIRRHRNLNIQLRDTIAHLDYAEESVHTTKRQLEEKISEVNNFKKELIEEFKKCKKGVEEEFEKKFEKIKEDYDELYEKLKRDQRDLERDQKILKKGTGERNKEFTETIATLRDKLRASETKNAQYRQDIRVRDEKLKKKDEEIEKLQKDGNRLKSTLQTLEKRVKQLRTEKERDDKEKEMFAKVAMNRKTSNPVPPVLNQSVPISITSNGPSRHPSSSSLTTFRKPSTSNRERGVSWADEPNEQSLEAVPQEFLMMPVKEMPGKFGKCTIYRDSLGETSKVTDTIANGLLFEYSNGDLRWVNRQNAVNIYISAVDKTVRIDLPTYNISIIHTFQRQVEVLRPGNNITLISIKRREVRTDLIYQNGMYKTEIFNRDGRYVTKDFSNQEVSRKYNPGTHTYRDNQCRYVLVTDYNDFELVEPEFRLRWYQGDPTGLNNQYILKIIGRPECSEKTLRLEVNLSTCEGTLETAEMIGDKRRKTTLFQWKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
512	Phosphorylation	KVAMNRKTSNPVPPV HHHHCCCCCCCCCCC	30.42	18806794
513	Phosphorylation	VAMNRKTSNPVPPVL HHHCCCCCCCCCCCC	42.02	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAS4_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAS4_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAS4_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMN1_CAEEL	lmn-1	physical	18692475
SAS4_CAEEL	sas-4	physical	18692475
CPG3_CAEEL	cpg-3	physical	18692475
CLH_CAEEL	chc-1	physical	18692475
EPG2_CAEEL	epg-2	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.