SARM1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SARM1_CAEEL
• UniProt AC: Q86DA5
• Protein Name: Sterile alpha and TIR motif-containing protein tir-1
• Gene Name: tir-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 1000
• Subcellular Localization: Cytoplasm .
• Protein Description: Required for both innate immune response and specification of AWC(OFF) neuron. [PubMed: 15048112]
• Protein Sequence: MLPNRKPPRPSPSFQSLNNNNQRFPLRRSLKIAQAHSLPTVPSEDAKDDDLITPELSTDFDFREIQHRYLMALQNEQDGETTSTDDAFFELDDDDDLSSPSVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIHEARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTCKLLKHRHLVYYLIFLVFSVTPTGSQERATSTRRKIQPSASTTSDRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
160	Phosphorylation	TPALSTVSVSLIHEA CCCCCEEEHHHHHHH	13.18	28854356
200	Phosphorylation	SEYRRFKSEGSTAGA HHHHHHHCCCCCCCC	44.47	28854356
203	Phosphorylation	RRFKSEGSTAGASLP HHHHCCCCCCCCCCC	15.84	28854356
240	Phosphorylation	RFLIQQDSVVNPSTK CHHCCCCCCCCCCCC	24.51	30078680
908	Phosphorylation	ITGELNRTTPTTKEM HHCCCCCCCCCCCCC	35.73	28854356
909	Phosphorylation	TGELNRTTPTTKEMP HCCCCCCCCCCCCCC	18.53	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SARM1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SARM1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SARM1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SARM1_CAEEL	tir-1	physical	14704431
CPR5_CAEEL	cpr-5	physical	14704431
SIAH1_CAEEL	siah-1	physical	14704431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.