S38A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S38A3_HUMAN
• UniProt AC: Q99624
• Protein Name: Sodium-coupled neutral amino acid transporter 3
• Gene Name: SLC38A3 {ECO:0000312|EMBL:AAH42875.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 504
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission..
• Protein Sequence: MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEEKTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPCPLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFLLMTMSLSFIIIDWASGTSRHGGNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	LVPNGKHSEGLLPVI ECCCCCCCCCCCCEE	36.52	22798277
46	Ubiquitination	ARSCMEGKSFLQKSP HHHHHCCHHHHHCCC	25.40	29967540
47	Phosphorylation	RSCMEGKSFLQKSPS HHHHCCHHHHHCCCC	41.88	20166139
51	Ubiquitination	EGKSFLQKSPSKEPH CCHHHHHCCCCCCCC	67.49	29967540
52	Phosphorylation	GKSFLQKSPSKEPHF CHHHHHCCCCCCCCC	22.80	30266825
54	Phosphorylation	SFLQKSPSKEPHFTD HHHHCCCCCCCCCCC	57.66	30266825
55	Ubiquitination	FLQKSPSKEPHFTDF HHHCCCCCCCCCCCC	77.86	29967540
60	Phosphorylation	PSKEPHFTDFEGKTS CCCCCCCCCCCCCCC	36.42	30266825
74	N-linked_Glycosylation	SFGMSVFNLSNAIMG CCCCHHHCCCHHHHH	40.16	UniProtKB CARBOHYD
120	Phosphorylation	SIHLLLKSSGVVGIR HHHHHHHCCCCEEEE	32.09	28111955
121	Phosphorylation	IHLLLKSSGVVGIRA HHHHHHCCCCEEEEE	33.74	28111955
129	Phosphorylation	GVVGIRAYEQLGYRA CCEEEEEEHHHCCCH	8.38	28111955
150	Phosphorylation	LAAALAITLQNIGAM HHHHHHHHHHHHHCC	19.38	-
159	Phosphorylation	QNIGAMSSYLYIIKS HHHHCCHHHHHHHHC	13.18	-
160	Phosphorylation	NIGAMSSYLYIIKSE HHHCCHHHHHHHHCC	9.02	-
247	N-linked_Glycosylation	CPLPPNFNNTTGNFS CCCCCCCCCCCCCCC	52.13	UniProtKB CARBOHYD
248	N-linked_Glycosylation	PLPPNFNNTTGNFSH CCCCCCCCCCCCCCE	34.57	UniProtKB CARBOHYD
252	N-linked_Glycosylation	NFNNTTGNFSHVEIV CCCCCCCCCCEEEEE	32.91	UniProtKB CARBOHYD
323	N-linked_Glycosylation	KKMQHISNLSIAVMY HHHHHHHHHHHHHHH	36.89	UniProtKB CARBOHYD
330	Phosphorylation	NLSIAVMYIMYFLAA HHHHHHHHHHHHHHH	3.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S38A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S38A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S38A3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SETB1_HUMAN	SETDB1	physical	16169070
NEDD4_HUMAN	NEDD4	physical	20737472

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00174: L-Asparagine
• DB00130: L-Glutamine
• DB00117: L-Histidine