RTNLD_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTNLD_ARATH
• UniProt AC: Q9FFS0
• Protein Name: Reticulon-like protein B4
• Gene Name: RTNLB4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 257
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Plays a role in the Agrobacterium-mediated plant transformation via its interaction with VirB2, the major component of the T-pilus..
• Protein Sequence: MVEDHKHEESILEKIVEKIHGHGDSSSLSDSDDDKKSTSSSSSSFKSKIYRLFGREKPVHKVLGGGKPADIFLWRNKKVSGGVLGAVTASWVLFELFEYHLLAFLCHFAIFALAALFLWSNACTFIHKSTPHIPEVHIPEDPILQLVSGLRIEINRGLTLLRNIASGKDVKKFILVIAGLWVLSIIGSCYNFLTLFYTATVLLFTIPVLYEKYEDKVDAYGEKAMREIKKQYAVLDEKVLRKVISKIPRGALNKKKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	KIHGHGDSSSLSDSD HHHCCCCCCCCCCCC	26.81	23776212
26	Phosphorylation	IHGHGDSSSLSDSDD HHCCCCCCCCCCCCC	39.78	23776212
27	Phosphorylation	HGHGDSSSLSDSDDD HCCCCCCCCCCCCCC	35.53	15308754
29	Phosphorylation	HGDSSSLSDSDDDKK CCCCCCCCCCCCCCC	36.70	19880383
31	Phosphorylation	DSSSLSDSDDDKKST CCCCCCCCCCCCCCC	39.29	19880383
37	Phosphorylation	DSDDDKKSTSSSSSS CCCCCCCCCCCCCHH	38.98	25368622
38	Phosphorylation	SDDDKKSTSSSSSSF CCCCCCCCCCCCHHH	41.32	25561503
39	Phosphorylation	DDDKKSTSSSSSSFK CCCCCCCCCCCHHHH	35.00	19880383
40	Phosphorylation	DDKKSTSSSSSSFKS CCCCCCCCCCHHHHH	34.04	25561503
42	Phosphorylation	KKSTSSSSSSFKSKI CCCCCCCCHHHHHHH	31.76	25561503
43	Phosphorylation	KSTSSSSSSFKSKIY CCCCCCCHHHHHHHH	41.56	25561503
44	Phosphorylation	STSSSSSSFKSKIYR CCCCCCHHHHHHHHH	38.35	25561503
245	Phosphorylation	KVLRKVISKIPRGAL HHHHHHHHHCCCCHH	27.76	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTNLD_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTNLD_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTNLD_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RTNLA_ARATH	BTI1	physical	15494553
RTNLB_ARATH	BTI2	physical	15494553
RAE1A_ARATH	RAB8	physical	15494553
RTNLD_ARATH	BTI3	physical	21798944
CYB5E_ARATH	CB5-E	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.
PubMed: 19376835

"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Plant Cell 16:2394-2405(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 15308754

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-27; SER-29 ANDSER-31, AND MASS SPECTROMETRY.
PubMed: 14506206