RRP1L_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP1L_DROME
• UniProt AC: Q9VJZ7
• Protein Name: Ribosomal RNA processing protein 1 homolog
• Gene Name: Nnp-1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 687
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in the generation of 28S rRNA..
• Protein Sequence: MVTRKKPVKRNAEAAEIQVEQEEDASQPKVAKELMVVAQEVKIIRALACNDVVERNRQIRILRKWFKARAGSSFPFNEDDFMRIWKGLYYTMWMSDKPLVQEELAEKLAQMVDSFGGNTACSLAYFSAFMRTMCQEYFGIDQWRMDKFLMLTRRMVRYLLRFLKQNNWNADLIAAFNSSMQLSVMSEQPKSRGMTMHYLDVFFEELAKAANGEITAAQVNMFLRPFVTYIATQRDAKLVAQCRTRVLYHLMYQSDLGRQYSEKYNAWKQMGFPTASIDDIEKLDSGFDEEDDEVNAEEEQPRATSLDPRAGNVDVHMPELPLNADCVLDELQTQLRTNDFNSKRRKGLRKLIQIFETYQRGEFPLGVRTMPKVEGQTLSEMVEQKVAALDKMEDEVFATGRKLKKLNKSKRKRLLQSINFEEVDEHNYDEVISKALPPELQKKVNYNAKVRSSINNAWVVEEVKEAEPKSKKAKKEEPPQQNKDDQTKVKKKSQLKPKNDQSKPKIEDQPTLKAEKEEPAKRKKLDHSKTKEEQSKPKTDEQPKPTPKVEGQSKAKPTPKTKAAGVDDDAPTNGWDAPLEDGEQDIFVPSRKLQVKQANSKLPQSTPKQPARAEFATPQTGSGKHVRIVTKSNCIYPKSDYYRQLKLSPQVPYDANRLPGKSALKPHWIPGPIHPSYKAKRLFNDTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
305	Phosphorylation	EEQPRATSLDPRAGN HHCCCCCCCCCCCCC	29.77	27626673
453	Phosphorylation	YNAKVRSSINNAWVV CCHHHHHHCCCCCHH	20.83	21082442
605	Phosphorylation	ANSKLPQSTPKQPAR HHCCCCCCCCCCCCC	44.74	22817900
606	Phosphorylation	NSKLPQSTPKQPARA HCCCCCCCCCCCCCC	29.29	22817900
617	Phosphorylation	PARAEFATPQTGSGK CCCCCCCCCCCCCCC	22.65	25749252
620	Phosphorylation	AEFATPQTGSGKHVR CCCCCCCCCCCCEEE	34.22	25749252
622	Phosphorylation	FATPQTGSGKHVRIV CCCCCCCCCCEEEEE	48.32	25749252
648	Phosphorylation	YYRQLKLSPQVPYDA HHHHCCCCCCCCCCC	16.23	19429919
653	Phosphorylation	KLSPQVPYDANRLPG CCCCCCCCCCCCCCC	28.91	25749252
662	Phosphorylation	ANRLPGKSALKPHWI CCCCCCCCCCCCCCC	44.76	22817900
686	Phosphorylation	AKRLFNDTL------ HHHHHCCCC------	35.16	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRP1L_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP1L_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP1L_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BOP1_DROME	CG5033	physical	22036573
RPF1_DROME	CG6712	physical	22036573
NOG1_DROME	Non1	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-617; THR-620 ANDSER-622, AND MASS SPECTROMETRY.
PubMed: 18327897