RIN2_HUMAN - dbPTM
RIN2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIN2_HUMAN
UniProt AC Q8WYP3
Protein Name Ras and Rab interactor 2
Gene Name RIN2
Organism Homo sapiens (Human).
Sequence Length 895
Subcellular Localization Cytoplasm .
Protein Description Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP..
Protein Sequence MTAWTMGARGLDKRGSFFKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDGGYSEEEDVKTCARDSGYDSLSNRLSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANGTERTRSPPPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGTKPTPIPPPRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20 (in isoform 2)Phosphorylation-3.4622210691
21 (in isoform 2)Phosphorylation-4.5322210691
37 (in isoform 2)Phosphorylation-24.7322210691
62PhosphorylationVRHKDGGYSEEEDVK
HCCCCCCCCCHHHHH		20.5926852163
63PhosphorylationRHKDGGYSEEEDVKT
CCCCCCCCCHHHHHH		41.6325056879
77PhosphorylationTCARDSGYDSLSNRL
HHHHHCCCCHHHHHH		13.3023403867
79PhosphorylationARDSGYDSLSNRLSI
HHHCCCCHHHHHHHH		25.8023403867
81PhosphorylationDSGYDSLSNRLSILD
HCCCCHHHHHHHHHH		24.6923403867
85PhosphorylationDSLSNRLSILDRLLH
CHHHHHHHHHHHHHH		20.1924719451
112PhosphorylationEEAAEVLQAQPPGIF
HHHHHHHHCCCCCEE		43.0327251275
128PhosphorylationVHKSTKMQKKVLSLR
EECCCHHHHHHHCCC		43.9327251275
134PhosphorylationMQKKVLSLRLPCEFG
HHHHHHCCCCCCCCC		5.9624719451
251PhosphorylationCLINGVHSIKTRTPS
HHHCCEEECCCCCCC		24.3128348404
281PhosphorylationPLFLKVHSQDLSGGL
CEEEEEECCCCCCCC		28.5128348404
285PhosphorylationKVHSQDLSGGLKRPS
EEECCCCCCCCCCCC		38.8223312004
293PhosphorylationGGLKRPSTRTPNANG
CCCCCCCCCCCCCCC		41.04-
295PhosphorylationLKRPSTRTPNANGTE
CCCCCCCCCCCCCCC		22.4522985185
300PhosphorylationTRTPNANGTERTRSP
CCCCCCCCCCCCCCC		26.9227251275
301PhosphorylationRTPNANGTERTRSPP
CCCCCCCCCCCCCCC		23.3122985185
304PhosphorylationNANGTERTRSPPPRP
CCCCCCCCCCCCCCC		29.3023927012
306PhosphorylationNGTERTRSPPPRPPP
CCCCCCCCCCCCCCC		40.9423927012
318PhosphorylationPPPPAINSLHTSPRL
CCCCCCCCCCCCCCC		18.5323927012
321PhosphorylationPAINSLHTSPRLART
CCCCCCCCCCCCCCC		45.8023403867
322PhosphorylationAINSLHTSPRLARTE
CCCCCCCCCCCCCCC		9.4023403867
328PhosphorylationTSPRLARTETQTSMP
CCCCCCCCCCCCCCC		37.4628857561
330PhosphorylationPRLARTETQTSMPET
CCCCCCCCCCCCCCC		36.2128857561
332PhosphorylationLARTETQTSMPETVN
CCCCCCCCCCCCCCC		34.1228857561
333PhosphorylationARTETQTSMPETVNH
CCCCCCCCCCCCCCC		23.6328857561
337PhosphorylationTQTSMPETVNHNKHG
CCCCCCCCCCCCCCC		22.27-
351PhosphorylationGNVALPGTKPTPIPP
CCCCCCCCCCCCCCC		31.7324114839
353PhosphorylationVALPGTKPTPIPPPR
CCCCCCCCCCCCCCH		43.1524719451
354PhosphorylationALPGTKPTPIPPPRL
CCCCCCCCCCCCCHH		35.0924114839
355PhosphorylationLPGTKPTPIPPPRLK
CCCCCCCCCCCCHHH		45.6924719451
366PhosphorylationPRLKKQASFLEAEGG
CHHHHHHHHEEECCC		28.0628731282
367PhosphorylationRLKKQASFLEAEGGA
HHHHHHHHEEECCCC		8.8427251275
371PhosphorylationQASFLEAEGGAKTLS
HHHHEEECCCCEECC		49.1124719451
379PhosphorylationGGAKTLSGGRPGAGP
CCCEECCCCCCCCCC		38.9627251275
381PhosphorylationAKTLSGGRPGAGPEL
CEECCCCCCCCCCCE		29.9727251275
382PhosphorylationKTLSGGRPGAGPELE
EECCCCCCCCCCCEE		40.0227251275
392PhosphorylationGPELELGTAGSPGGA
CCCEECCCCCCCCCC		40.2323312004
395PhosphorylationLELGTAGSPGGAPPE
EECCCCCCCCCCCCC		20.2223312004
415PhosphorylationCTRAPPPSSESRPPC
CCCCCCCCCCCCCCC		53.1424719451
436PhosphorylationLSDMSISTSSSDSLE
CCCCEECCCCCCCCC		30.8427251275
437PhosphorylationSDMSISTSSSDSLEF
CCCEECCCCCCCCCC		22.5127251275
438PhosphorylationDMSISTSSSDSLEFD
CCEECCCCCCCCCCC		37.9527251275
439PhosphorylationMSISTSSSDSLEFDR
CEECCCCCCCCCCCC		30.8727251275
441PhosphorylationISTSSSDSLEFDRSM
ECCCCCCCCCCCCCC		31.5727251275
444PhosphorylationSSSDSLEFDRSMPLF
CCCCCCCCCCCCCCC		13.1924719451
447PhosphorylationDSLEFDRSMPLFGYE
CCCCCCCCCCCCEEE		26.9622210691
457PhosphorylationLFGYEADTNSSLEDY
CCEEECCCCCCCCCC		44.0128348404
459PhosphorylationGYEADTNSSLEDYEG
EEECCCCCCCCCCCC		38.0922210691
460PhosphorylationYEADTNSSLEDYEGE
EECCCCCCCCCCCCC		37.5428348404
464PhosphorylationTNSSLEDYEGESDQE
CCCCCCCCCCCCCCC		19.2328348404
468PhosphorylationLEDYEGESDQETMAP
CCCCCCCCCCCCCCC		56.2922210691
472PhosphorylationEGESDQETMAPPIKS
CCCCCCCCCCCCCCC		17.0128348404
484PhosphorylationIKSKKKRSSSFVLPK
CCCCCCCCCCCHHHH		38.9330266825
485PhosphorylationKSKKKRSSSFVLPKL
CCCCCCCCCCHHHHH		31.6530266825
486PhosphorylationSKKKRSSSFVLPKLV
CCCCCCCCCHHHHHH		22.1825159151
487PhosphorylationKKKRSSSFVLPKLVK
CCCCCCCCHHHHHHH		7.6527251275
494UbiquitinationFVLPKLVKSQLQKVS
CHHHHHHHHHHHHHH		42.81-
501PhosphorylationKSQLQKVSGVFSSFM
HHHHHHHHCCHHHCC		35.9528348404
505PhosphorylationQKVSGVFSSFMTPEK
HHHHCCHHHCCCHHH		21.91-
506PhosphorylationKVSGVFSSFMTPEKR
HHHCCHHHCCCHHHH		13.9427251275
508PhosphorylationSGVFSSFMTPEKRMV
HCCHHHCCCHHHHHH		7.0727251275
509PhosphorylationGVFSSFMTPEKRMVR
CCHHHCCCHHHHHHH		26.7022199227
513PhosphorylationSFMTPEKRMVRRIAE
HCCCHHHHHHHHHHH		27.4527251275
533PhosphorylationCTYFGCLVQDYVSFL
CCHHHHHHHHHHHHH		4.7824719451
535PhosphorylationYFGCLVQDYVSFLQE
HHHHHHHHHHHHHHH		38.0224719451
550PhosphorylationNKECHVSSTDMLQTI
CCCCCCCHHHHHHHH		27.6027251275
562PhosphorylationQTIRQFMTQVKNYLS
HHHHHHHHHHHHHHH		31.34-
593UbiquitinationQIDVVLEKAMHKCIL
HHHHHHHHHHHHHHH		47.01-
612UbiquitinationGHVEAMLKDFHMADG
CHHHHHHHHHHHCCC		45.31-
622UbiquitinationHMADGSWKQLKENLQ
HHCCCCHHHHHHHHH		47.66-
625UbiquitinationDGSWKQLKENLQLVR
CCCHHHHHHHHHHHH		41.90-
653UbiquitinationPDFVDVEKIKVKFMT
CCCCCHHHHHHEEEE		47.91-
665PhosphorylationFMTMQKMYSPEKKVM
EEECCCCCCHHHHHH		28.2729083192
666PhosphorylationMTMQKMYSPEKKVML
EECCCCCCHHHHHHH		24.0829083192
746PhosphorylationTSAYGALSLIKNFQE
HHHHHHHHHHHHCCH		27.7524719451
767PhosphorylationLSSETRDTLRQWHKR
HCHHHHHHHHHHHHH		22.1323403867
776PhosphorylationRQWHKRRTTNRTIPS
HHHHHHCCCCCCCCC		32.2428348404
777PhosphorylationQWHKRRTTNRTIPSV
HHHHHCCCCCCCCCH		22.3828348404
780PhosphorylationKRRTTNRTIPSVDDF
HHCCCCCCCCCHHHH		39.0328348404
783PhosphorylationTTNRTIPSVDDFQNY
CCCCCCCCHHHHHHH		34.0427499020
790PhosphorylationSVDDFQNYLRVAFQE
CHHHHHHHHHHHHHH		5.7728152594
829PhosphorylationCAEKFKVGDPEEYSL
HHHHCCCCCHHHEEE		45.4027251275
832PhosphorylationKFKVGDPEEYSLFLF
HCCCCCHHHEEEEEE		74.4527251275
839PhosphorylationEEYSLFLFVDETWQQ
HHEEEEEEECHHHHH		5.2227642862
857UbiquitinationDTYPQKIKAELHSRP
CCCCHHHHHHHHCCC		42.73-
930Phosphorylation------------------------------------------
------------------------------------------		27642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIN2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIN2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIN2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB5B_HUMANRAB5Bphysical
11733506
RIN2_HUMANRIN2physical
11733506
NAA11_HUMANNAA11physical
28514442
NAA10_HUMANNAA10physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613075MACS syndrome (MACS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIN2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-509, AND MASSSPECTROMETRY.

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