RHBT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHBT3_MOUSE
• UniProt AC: Q9CTN4
• Protein Name: Rho-related BTB domain-containing protein 3
• Gene Name: Rhobtb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 611
• Subcellular Localization: Golgi apparatus.
• Protein Description: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity)..
• Protein Sequence: MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMTSSFHGIRPPQLEQPEKMPVLKAEASHYHSDLNNLLLCCQCVDVVFYHPEVTGVVEAHKIVLCSVSHVFMLLFNVKSPADIQDSSIIRTTQDLFAINRDAVLPGASQEAPSNPPLPVIVKDALFCSCLSDILRFIYSGAFQWEELEEDVRRKLKDSGDVSDIIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
215	Phosphorylation	KKRKMTSSFHGIRPP HHCCCCCCCCCCCCC	16.46	25338131
296	Phosphorylation	SPADIQDSSIIRTTQ CCHHCCCCCCEEHHH	13.68	28285833
377	Acetylation	DVSDIIEKVKCILKT CHHHHHHHHHHHHCC	36.26	7718291
379	Acetylation	SDIIEKVKCILKTPG HHHHHHHHHHHCCCC	26.99	7718301
397	Phosphorylation	CLRNCKTYQARKPLW ECCCCCCEECCCCEE	5.91	29514104
453	Phosphorylation	AAMFNGNYMEAKSVL HHHHCCCCEEEEEEE	9.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHBT3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHBT3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHBT3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRC41_MOUSE	Lrrc41	physical	22709582
VHL_MOUSE	Vhl	physical	26215701
EGLN1_MOUSE	Egln1	physical	26215701

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.