RGRF2_HUMAN - dbPTM
RGRF2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGRF2_HUMAN
UniProt AC O14827
Protein Name Ras-specific guanine nucleotide-releasing factor 2
Gene Name RASGRF2
Organism Homo sapiens (Human).
Sequence Length 1237
Subcellular Localization Cytoplasm. Cell membrane
Peripheral membrane protein. Endoplasmic reticulum membrane
Peripheral membrane protein. Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity)..
Protein Description Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation..
Protein Sequence MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationSKKTAEASRWHEKWF
CHHHHHHHHHHHHHH		27.66-
76PhosphorylationEGCSCERTPAPPRAG
ECCCCCCCCCCCCCC		11.0829396449
97PhosphorylationRDALDKQYYFTVLFG
HHHCCCCEEEEEEEC		13.2922817900
98PhosphorylationDALDKQYYFTVLFGH
HHCCCCEEEEEEECC		7.1224043423
100PhosphorylationLDKQYYFTVLFGHEG
CCCCEEEEEEECCCC		10.5224043423
180PhosphorylationTEIERLKSEIIALNK
HHHHHHHHHHHHHHC		38.3224719451
188PhosphorylationEIIALNKTKERMRPY
HHHHHHCCHHHCCCC		36.7424719451
207AcetylationEDEDPDIKKIKKVQS
CCCCCCHHHHHHHHH		56.6920167786
465PhosphorylationQTFIRQGSLIQVPSV
CHHHHCCCEEECCCE		17.60-
471PhosphorylationGSLIQVPSVERGKLS
CCEEECCCEECCCCC		37.4426091039
484PhosphorylationLSKVRLGSLSLKKEG
CCCEEECCCCCCCCC		21.2723401153
486PhosphorylationKVRLGSLSLKKEGER
CEEECCCCCCCCCCC		39.5829514088
536PhosphorylationLIEEPDASDDDSKGS
EECCCCCCCCCCCCC		49.2927251275
623PhosphorylationARLHKDDTDICFSKT
CCCCCCCCCCCCCCC		37.0823090842
628PhosphorylationDDTDICFSKTLNSCK
CCCCCCCCCCCCCCC		21.9623090842
630PhosphorylationTDICFSKTLNSCKVP
CCCCCCCCCCCCCCC		29.9424719451
633PhosphorylationCFSKTLNSCKVPQIR
CCCCCCCCCCCCCCC		20.5923401153
718PhosphorylationEHLVDGKSPRLCRKF
CCCCCCCCHHHHHHC		22.3023401153
726PhosphorylationPRLCRKFSSPPPLAV
HHHHHHCCCCCCEEE		44.9923401153
727PhosphorylationRLCRKFSSPPPLAVS
HHHHHCCCCCCEEEC		44.5525106551
734PhosphorylationSPPPLAVSRTSSPVR
CCCCEEECCCCCCCC		25.0030131370
736PhosphorylationPPLAVSRTSSPVRAR
CCEEECCCCCCCCCC		26.5028102081
737PhosphorylationPLAVSRTSSPVRARK
CEEECCCCCCCCCCC		31.3815128856
738PhosphorylationLAVSRTSSPVRARKL
EEECCCCCCCCCCCC		27.1428102081
746PhosphorylationPVRARKLSLTSPLNS
CCCCCCCCCCCCCCC		32.4123401153
748PhosphorylationRARKLSLTSPLNSKI
CCCCCCCCCCCCCCC		25.5626657352
749PhosphorylationARKLSLTSPLNSKIG
CCCCCCCCCCCCCCC		32.4629496963
753PhosphorylationSLTSPLNSKIGALDL
CCCCCCCCCCCCEEE		33.0822199227
761PhosphorylationKIGALDLTTSSSPTT
CCCCEEECCCCCCCC		25.0529116813
762PhosphorylationIGALDLTTSSSPTTT
CCCEEECCCCCCCCC		33.6329116813
767PhosphorylationLTTSSSPTTTTQSPA
ECCCCCCCCCCCCCC		38.4326657352
768PhosphorylationTTSSSPTTTTQSPAA
CCCCCCCCCCCCCCC		31.0927251275
769PhosphorylationTSSSPTTTTQSPAAS
CCCCCCCCCCCCCCC		25.8927251275
770PhosphorylationSSSPTTTTQSPAASP
CCCCCCCCCCCCCCC		25.5927251275
772PhosphorylationSPTTTTQSPAASPPP
CCCCCCCCCCCCCCC		17.8927251275
776PhosphorylationTTQSPAASPPPHTGQ
CCCCCCCCCCCCCCC		39.7929116813
781PhosphorylationAASPPPHTGQIPLDL
CCCCCCCCCCCCCCH		36.2324076635
793PhosphorylationLDLSRGLSSPEQSPG
CCHHCCCCCCCCCCC		46.8224076635
794PhosphorylationDLSRGLSSPEQSPGT
CHHCCCCCCCCCCCC		37.1824076635
798PhosphorylationGLSSPEQSPGTVEEN
CCCCCCCCCCCCCCC		24.5224076635
801PhosphorylationSPEQSPGTVEENVDN
CCCCCCCCCCCCCCC		28.2929116813
838PhosphorylationADRAGVESSPAADTT
CHHCCCCCCCCCCCC		38.9323312004
839PhosphorylationDRAGVESSPAADTTE
HHCCCCCCCCCCCCC		12.6826699800
844PhosphorylationESSPAADTTELSPCR
CCCCCCCCCCCCCCC		19.9023401153
845PhosphorylationSSPAADTTELSPCRS
CCCCCCCCCCCCCCC		35.1626699800
848PhosphorylationAADTTELSPCRSPST
CCCCCCCCCCCCCCC		18.7429116813
852PhosphorylationTELSPCRSPSTPRHL
CCCCCCCCCCCCCCC		29.8923401153
854PhosphorylationLSPCRSPSTPRHLRY
CCCCCCCCCCCCCEE		52.9026699800
855PhosphorylationSPCRSPSTPRHLRYR
CCCCCCCCCCCCEEC		27.9426699800
972PhosphorylationANILRALSQDDQDDI
HHHHHHHCCCCCCCH		30.49-
1000PhosphorylationMKAECFESLSAMELA
HHHHHHHHCCHHHHH		13.84-
1002PhosphorylationAECFESLSAMELAEQ
HHHHHHCCHHHHHHH		34.54-
1040PhosphorylationKLDKNERTPYIMKTS
ECCCCCCCCCCEECC		17.7929396449
1059PhosphorylationDMSNLVASQIMNYAD
HHHHHHHHHHHHHHC		16.8629759185
1090PhosphorylationICRCLHNYNGVLEIT
HHHHHHHCCCHHHHH		11.5322817900
1098PhosphorylationNGVLEITSALNRSAI
CCHHHHHHHCCHHHH		36.10-
1106PhosphorylationALNRSAIYRLKKTWA
HCCHHHHHHHHHHHH		15.0322817900
1111PhosphorylationAIYRLKKTWAKVSKQ
HHHHHHHHHHHHHHH		29.12-
1129PhosphorylationLMDKLQKTVSSEGRF
HHHHHHHHHCCCCHH		16.8022210691
1131PhosphorylationDKLQKTVSSEGRFKN
HHHHHHHCCCCHHHH		28.0922210691
1132PhosphorylationKLQKTVSSEGRFKNL
HHHHHHCCCCHHHHH		39.4722210691
1198PhosphorylationEIRQFQQTSYRIDHQ
HHHHHHHHCCCCCCC		19.5529449344
1199PhosphorylationIRQFQQTSYRIDHQP
HHHHHHHCCCCCCCH		14.2129449344
1200PhosphorylationRQFQQTSYRIDHQPK
HHHHHHCCCCCCCHH		18.2529449344
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
737SPhosphorylationKinaseCDK5Q00535
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGRF2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGRF2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RGRF2_HUMANRASGRF2physical
17353931
PMVK_HUMANPMVKphysical
17353931
EPIPL_HUMANEPPK1physical
17353931
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGRF2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"p35/cyclin-dependent kinase 5 phosphorylation of ras guaninenucleotide releasing factor 2 (RasGRF2) mediates Rac-dependentextracellular signal-regulated kinase 1/2 activity, altering RasGRF2and microtubule-associated protein 1b distribution in neurons.";
Kesavapany S., Amin N., Zheng Y.-L., Nijhara R., Jaffe H., Sihag R.,Gutkind J.S., Takahashi S., Kulkarni A., Grant P., Pant H.C.;
J. Neurosci. 24:4421-4431(2004).
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDK5R1,PHOSPHORYLATION AT SER-737 BY CDK5, AND MUTAGENESIS OF SER-737.

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