RGLG2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGLG2_ARATH
• UniProt AC: Q9LY87
• Protein Name: E3 ubiquitin-protein ligase RGLG2 {ECO:0000305}
• Gene Name: RGLG2 {ECO:0000303|PubMed:17586653}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 468
• Subcellular Localization: Cell membrane ; Lipid-anchor . Nucleus . Translocates to the nucleus under salt stress.
• Protein Description: E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance. [PubMed: 17586653 Mediates ubiquitination and subsequent proteasomal degradation of ERF053 in response to drought stress. Acts as a negative regulator of drought stress response]
• Protein Sequence: MGTGNSKENWRQSSFRSTSASSASPSSSSWASQQSYPQYGAESYNYPPPPSYAQPPEYTQPPPPLYSTQPYSAPSYSAPPSQSYGSDNKKRLERKYSKISDDYSSLEQVTEALARAGLESSNLIVGIDFTKSNEWTGARSFNRKSLHFIGSSPNPYEQAITIIGRTLAAFDEDNLIPCYGFGDASTHDQDVFSFNSEDRFCNGFEEVLSRYKEIVPQLKLAGPTSFAPIIDMAMTIVEQSGGQYHVLVIIADGQVTRSVDTENGQLSPQEQKTVDAIVQASKLPLSIVLVGVGDGPWDMMREFDDNIPARAFDNFQFVNFTEIMAKNKAQSLKETEFALSALMEIPQQYKATIELNLLGRRNGYIPERFPLPPPMRGGSSSYNSPKPSRLPSFKPSVPPHPTEGYHVRSSPVPPPTSSASDNQLCPICLSNPKDMAFGCGHQTCCECGPDLQMCPICRAPIQTRIKLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGTGNSKEN ------CCCCCCHHH	42.18	17586653
97	Phosphorylation	KRLERKYSKISDDYS HHHHHHHHHHCCCCH	26.92	27545962
392	Phosphorylation	PKPSRLPSFKPSVPP CCCCCCCCCCCCCCC	50.96	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGLG2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGLG2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGLG2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERF53_ARATH	AT2G20880	physical	22095047
UBC35_ARATH	UBC35	physical	17586653
RGLG1_ARATH	RGLG1	genetic	17586653

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.