RGF1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGF1B_HUMAN
• UniProt AC: Q0VAM2
• Protein Name: Ras-GEF domain-containing family member 1B
• Gene Name: RASGEF1B
• Organism: Homo sapiens (Human).
• Sequence Length: 473
• Subcellular Localization: Early endosome. Late endosome. Midbody . May shuttle between early and late endosomes (By similarity). Localizes to midbody at telophase..
• Protein Description: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro)..
• Protein Sequence: MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPQTPPFSAMF ----CCCCCCCCHHC	27.36	24043423
8	Phosphorylation	MPQTPPFSAMFDSSG CCCCCCCCHHCCCCC	25.29	24043423
13	Phosphorylation	PFSAMFDSSGYNRNL CCCHHCCCCCCCCCH	17.88	24043423
14	Phosphorylation	FSAMFDSSGYNRNLY CCHHCCCCCCCCCHH	47.33	24043423
16	Phosphorylation	AMFDSSGYNRNLYQS HHCCCCCCCCCHHHC	16.94	24043423
69	Phosphorylation	YIFTFLLSSRLFMHP HHHHHHHHCCCCCCH	18.63	24719451
70	Phosphorylation	IFTFLLSSRLFMHPY HHHHHHHCCCCCCHH	32.73	24719451
77	Phosphorylation	SRLFMHPYELMAKVC CCCCCCHHHHHHHHH	13.66	17053785
148	Phosphorylation	IASGEEQTYRKNVQQ HHCCCHHHHHHHHHH	28.68	24719451
149	Phosphorylation	ASGEEQTYRKNVQQM HCCCHHHHHHHHHHH	21.20	24719451
170	Phosphorylation	KLAALSQYEEVLAKI HHHHHHHHHHHHHHH	15.64	-
178	Phosphorylation	EEVLAKISSTSTDRL HHHHHHHCCCCCCCE	27.19	24702127
179	Phosphorylation	EVLAKISSTSTDRLT HHHHHHCCCCCCCEE	29.83	24702127
180	Phosphorylation	VLAKISSTSTDRLTV HHHHHCCCCCCCEEE	28.93	24702127
181	Phosphorylation	LAKISSTSTDRLTVL HHHHCCCCCCCEEEE	30.20	24702127
182	Phosphorylation	AKISSTSTDRLTVLK HHHCCCCCCCEEEEE	25.81	24702127
186	Phosphorylation	STSTDRLTVLKTKPQ CCCCCCEEEEECCCC	25.37	27461979
266	Phosphorylation	VEWFNRLSYLVATEI HHHHHHHHHHHHHHH	17.12	-
267	Phosphorylation	EWFNRLSYLVATEIC HHHHHHHHHHHHHHC	15.13	-
271	Phosphorylation	RLSYLVATEICMPVK HHHHHHHHHHCCCCC	20.57	27422710
323	Phosphorylation	PVSRLKKTWAKVKTA HHHHHHHHHHHHHHC	29.12	-
467	Phosphorylation	DRWKSLRSSLLGRV- HHHHHHHHHHHCCC-	30.54	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGF1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGF1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGF1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CO1A1_HUMAN	COL1A1	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-77, AND MASSSPECTROMETRY.
PubMed: 17053785